Birla Institute of Technology, Mesra
Dr. Manish Kumar
Professor, Bioengineering and Biotechnology
M.Sc., Ph.D. 		Contact Address
Permanent Address Dept. of Bioengineering & Biotechnology
Local Address Dept. of Bioengineering & Biotechnology
Phone (Office) 916512276223
Phone Residence 916512276223
Email Id manish@bitmesra.ac.in
Joined Institute on : 4-May-2005
  Work Experience
 
Teaching : 18 Years

Research : 20 Years
  Research Areas
 
  • Environmental Biotechnology
  • Plant-Pathogen Interactions
  • Chromatography and Mass Spectrometry
  • Metabolomics
  Award and Honours
 
  1. BIT Faculty Appreciation Award (BITFAA’24) for significant contribution to the developmental activities of the Institute.
  Publications
 

International Peer Reviewed Journals:

2024

  1. Afreen U., Mukhopadhyay K., Kumar M. (2024) Identification of novel microRNAs and their target genes associated with stress-tolerant phytohormones in wheat (Triticum aestivum L.) during leaf rust pathogenesis. Journal of Plant Diseases and Protection. 10.1007/s41348-024-01005-w
  2. Srivastava P., Rai, A., Kumar M. (2024) Expression Profile of Diagnostic Genes in Oral Submucous Fibrosis. Pathology Research and Practice. Article Id- 155416. https://doi.org/10.1016/j.prp.2024.155416.
  3. Afreen U., Pandey A., Jha S. K., Kumar M. & Mukhopadhyay K. (2024) Comprehensive analysis of hairpin small RNAs involved in resistance and pathogenesis during wheat–Puccinia triticina interactions. Physiologia Plantarum, e14516. https://doi.org/ 10.1111/ppl.14516.  
  4. Afreen U., Kumar M. (2024) 5-mC methylation study of sORFs in 3?UTR of Transcription factor JUNGBRUNNEN 1-like during leaf rust pathogenesis in wheat. Mol Biol Rep. 10.1007/s11033-024-09718-9. 
  5. Gidhi A, Jha S. K., Kumar M., Mukhopadhyay K. (2024) The F-box protein encoding genes of the leaf-rust fungi Puccinia triticina: Genome-wide identification, characterization and expression dynamics during pathogenesis. Archives of Microbiology. 10.1007/s00203-024-03936-2.
  6. Afreen U., Kumar M., Mukhopadhyay K. (2024) Unraveling the role of microRNA-like RNAs in enhancing Puccinia triticina pathogenicity in wheat by high-throughput sequencing data. Physiological and Molecular Plant Pathology Https://doi.org/10.1016/j.pmpp.2024.102267
  7. Dhandhanya U., Mukhopadhyay, Kumar M. (2024) An Accretive Detection Method for In Silico Identification and Validation of Circular RNAs in Wheat (Triticum aestivum L.) using RT-qPCR. Mol Biol Rep 51, 162. https://doi.org/10.1007/s11033-023-09138-1
  8. Shree P., Aggarwal Y., Kumar M., Majhee L., Singh N. N., Prakash O., Chandra A., Mahuli S. A., Shamsi S., Rai A. (2024) Saliva-based diagnostic prediction of Oral Squamous cell carcinoma using FTIR spectroscopy. Indian J Otolaryngol Head Neck Surg. https://doi.org/10.1007/s12070-023-04294-z

2023

  1. Gidhi A.,Mohapatra A., Fatima M., Jha S.K., Kumar M., Mukhopadhyay K. (2023) Insights of auxin signaling F-box genes in wheat (Triticum aestivum L.) and their dynamic expression during the leaf rust infection. Protoplasma. 260:723-739. https://doi.org/10.1007/s00709-022-01808-4.

2022

  1. Akansha, K., Yadav, A.N., Kumar, M. Chakraborty D., Sachan S. G. (2022) Decolorization and degradation of reactive orange 16 by Bacillus stratosphericus SCA1007. Folia Microbiol 67, 91–102. https://doi.org/10.1007/s12223-021-00914-9. IF-2.099.
  2. Shweta Singh S., Banerjee M., Kumar M. (2022) Analysis of secondary metabolites present in Phlogacanthus thyrsiflorus Nees plant parts using LC-ESI-MS, South African Journal of Botany, 149, 916-922. https://doi.org/10.1016/j.sajb.2021.08.013. IF-2.315

2021

  1. Gaggar P, Kumar M, Mukhopadhyay K (2021) Genome-scale identification, in silico characterization and interaction study between wheat SNARE and NPSN gene families involved in vesicular transport. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 18(6):2492-2501. DOI: 10.1109/TCBB.2020.2981896. IF-3.71

2020

  1. Chandra S, Satapathy L., Basu S., Jha S., Kumar M, Mukhopadhyay K. (2020) Characterization of the leaf rust responsive ARF genes in wheat (Triticum aestivum L.). Plant Cell Rep 39, 1639–1654. https://doi.org/10.1007/s00299-020-02591-3. IF- 4.570
  2. Singh S., Banerjee M., Kumar M. (2020) Rhizobium rhizogenes Mediated Hairy Root Transformation and Analysis of Secondary Metabolites in Phlogacanthus thyrsiflorus Nees Hairy Roots using GC-MS. Journal of Scientific & Industrial Research, 79:590-594. IF-1.056
  3. Singh A, Ghosh Sachan S, Mukhopadhyay K, Kumar M, Sachan A (2020) A rapid and simple ultra-high-performance liquid chromatography method for the simultaneous determination of methoxyphenol derivatives involved in the eugenol catabolic pathway. Journal of Separation Science 43(5): 848-1018. DOI: 10.1002/jssc.201900939. IF-3.645
  4. Gidhi A, Kumar M, Mukhopadhyay K (2020) The Auxin Response Factor gene family in wheat (Triticum aestivum L.): Genome-wide identification, characterization and expression analyses in response to leaf rust. South African Journal of Botany. 140,312-325. DOI:1 0.1016/j.sajb.2020.06.017. IF-2.315

2019

  1. Dutta S., Kumar M. and Mukhopadhyay K. (2019) Identification and validation of leaf rust responsive wheat isomiRs and their target genes in both wheat and Puccinia triticina. Tropical Plant Biol. 12, 318–335. DOI: 10.1007/s12042-019-09235-1. IF-1.512
  2. Dutta S., Kumar D., Jha S. Prabhu K. V., Kumar M. and Mukhopadhyay K. (2019) Leaf rust (Puccinia triticina) mediated RNAi in wheat (Triticum aestivum L.) prompting host-susceptibility. Functional & Integrative Genomics.19, 437–452 DOI: 10.1007/s10142-019-00655-6. IF-3.410
  3. Dutta S., Kumar M. and Mukhopadhyay K. (2019) Development of a rapid RNA extraction procedure from urediniospores of the leaf rust fungus, Puccinia triticina. Journal of Microbiological Methods. DOI: https://doi.org/10.1016/j.mimet.2019.01. 010. IF-2.363

2018

  1. Singh S., Banerjee M., Kumar M. (2018) Gas Chromatography analysis of different plant parts of Phlogacanthus thyrsiflorus Nees. Res. J. Biotech. 13 (3):66-70. E-ISSN 2278-4535; PRINT-ISSN 0973-6263.
  2. Satapathy L., Kumar D., Kumar M., Mukhopadhyay K. (2018) Functional and DNA–protein binding studies of WRKY transcription factors and their expression analysis in response to biotic and abiotic stress in wheat (Triticum aestivum L.). 3 Biotech. 8: 40. https://doi.org/10.1007/s13205-017-1064-3. IF-2.406
  3. Singh S., Sarkar B., Mukhopadhyay K., Banerjee M., Kumar M. (2018) Antioxidants, DNA Damage Protective Properties and Antibacterial Activity of Leaf Extract of Phlogacanthus thyrsiflorus Nees. Asian Jr. of Microbiol. Biotech. Env. Sc. 20: S145-S151.

2017

  1. Singh D., Kumar D., Satapathy L., Pathak J., Chandra S., Riaz A., Bhaganagre G., Dhariwal R., Kumar M., Prabhu K. V., Balyan H.S., Gupta P. K., Mukhopadhyay K. (2017) Insights of Lr28 mediated wheat leaf rust resistance: Transcriptomic approach. Gene 637: 72–89. https://doi.org/10.1016/j.gene. 2017.09.028. IF-3.688
  2. Dutta S., Kumar D., Jha S. Prabhu K. V., Kumar M. and Mukhopadhyay K. (2017) Identification and molecular characterization of a trans-acting small interfering RNA producing locus regulating leaf rust responsive gene expression in wheat (Triticum aestivum L.). Planta. 246(5):939-957 DOI 10.1007/s00425-017-2744-2. IF: 4.116
  3. Chandra S., Singh D., Pathak J., Kumari S., Kumar M., Poddar P., Balyan H. S., Prabhu K.V., Gupta P. K. and Mukhopadhyay K. (2017) SNP discovery from next-generation transcriptome sequencing data and their validation using KASP assay in wheat (Triticum aestivum L.). Mol Breeding. 37:92-1-15. DOI 10.1007/s11032-017-0696-7. IF: 2.589
  4. Chandra S., Kazmi A. Z., Ahmed Z. Choudhary G., Kumari V., Kumar M and Mukhopadhyay K. (2017) Genome-wide identification and characterization of NB-ARC resistant genes in wheat (Triticum aestivum L.) and their expression during leaf rust infection. Plant Cell Rep. 36:1097–1112. DOI 10.1007/s00299-017-2141-0. IF-4.570
  5. Chandra S, Halder P, Kumar M, Mukhopadhyay K. (2017) Genome-wide identification, cloning and characterization of SNARE genes in bread wheat (Triticum aestivum L.) and their response to leaf rust. Agri Gene. 3:12-20.http://dx.doi.org/10.1016/j.aggene.2016.11.002.

2016

  1. Kumar D., Dutta S., Singh D., Prabhu K. V., Kumar M., Mukhopadhyay KUncovering leaf rust responsive miRNAs in wheat (Triticum aestivum L.) using high throughput sequencing and prediction of their targets through degradome analysis. Planta.245:161–182. DOI 10.1007/s00425-016-2600-9. IF – 4.116
  2. Chandra S., Singh D, Pathak J, Kumari S, Kumar M, Poddar R, Balyan HS, Gupta P K., Prabhu K V., Mukhopadhyay K. (2016) De Novo Assembled Wheat Transcriptomes Delineate Differentially Expressed Host Genes in Response to Leaf Rust Infection. PLoS ONE 11(2): e0148453. doi: 10.1371/journal.pone.0148453. IF – 3.54
  3. Chandra S., Mukhopadhyay K., Kumar M. (2016) Mining Single Nucleotide Polymorphism from publicly available ESTs of bread wheat (Triticum aestivum L.). Int J Pharm Pharm Sci., 8 (1):189-196.IF – 1.59

2015

  1. Kumar A., Sasmal. D., Sharma N., Bhaskar A., Chandra S., Mukhopadhyay K., Kumar M. (2015) Deltamethrin, a pyrethroid insecticide, could be a promising candidate as an anticancer agent. Medical Hypotheses. 85:145-147.IF – 1.538

2014

  1. Kumar M. (2014) Estimation and characterization of flavonoids in two different forma of O. tenuiflorum. International Journal of Basic and Applied Biology.2(2):34-37.
  2. Bhaskar A., Mukhopadhyay K. and Kumar M. (2014) Effect of polysorbate-80 concentration on G-CSF formulation using liquid chromatography. Int J Pharm Pharm Sci., 6(9):299-302. (IF= 1.59)
  3. Kumar D., Kapoor A., Singh D., Satapathy, L., Singh A., Kumar M., Prabhu K. V., Mukhopadhyay K. (2014) Functional characterization of a WRKY Transcription Factor of wheat and its expression analysis during leaf rust pathogenesis. Functional Plant Biology.41:1295–1309. http://dx.doi.org/10.1071/FP14077. (IF= 3.10)
  4. Satapathy, L., Singh D., Ranjan P., Kumar M., Prabhu K. V., Mukhopadhyay K. (2014) Transcriptome-wide analysis of WRKY transcription factors in wheat and their leaf rust responsive expression profiling. Mol Genet Genomics. 289:1289–1306. DOI 10.1007/s00438-014-0890-9. (IF= 3.291)
  5. Kumar D., Singh D., Kanodia P., Prabhu K. V., Kumar M., Mukhopadhyay K. (2014) Discovery of novel leaf rust responsive microRNAs in wheat and prediction of their target genes. Journal of Nucleic Acids. Article ID 570176, 12 pages. http://dx.doi.org/10.1155/2014/570176. IF – 2.98
  6. Vyas P., Haque I., Kumar M., Bandopadhyay R. and Mukhopadhyay K. (2014) Photocontrol of differential gene expression and alterations in foliar anthocyanin accumulation: a comparative study using red and green forma Ocimum tenuiflorum L. Acta Physiol Plant. 36:2091–2102. DOI 10.1007/s11738-014-1586-9. (IF= 2.354).
  7. Renu I.K., Haque I., Kumar M., Poddar R., Rai A., Bandopadhyay R. and Mukhopadhyay K. (2014) Characterization and functional analysis of Eugenol O-methyltransferase gene reveal metabolite shifts, chemotype specific differential expression and developmental regulation in Ocimum tenuiflorum L. Mol Biol Rep.  41:1857–1870. DOI 10.1007/s11033-014-3035-7. (IF= 2.316).
  8. Manaswita S., Bhaskar A., Poddar R., Mukhopadhyay K. and Kumar M. (2014)Insilicostudy to evaluate the molecular interactions between somatostatin and its receptor (sstr5). World Journal of Pharmacy and Pharmaceutical Sciences. 3(3): 1824-1837. ISSN 2278 – 4357.

2013

  1. Mehta K., Poddar R., Mukhopadhyay K. and Kumar M. (2013). Insight into interaction of γ- synuclein inhibiting α- synuclein oligomers – A possible strategy to cure Parkinson’s disease. Int. J. Adv. Biotechnol. Res., 4(4): 488-495.ISSN  0976-2612. (IF= 1.506).

2009

  1. Sinha M., Gupta D. K., Kumar M., Srivastava R., and Sinha R. (2004) Suitability of an earthworm Perionyx sansibaricus (Michaelsen) as verm meal for catfish Clarius batrachus (Linn). Aquacult, Vol. 5 (2):199-206.
  2. Sinha M., Srivastava R., Gupta D.K. and Kumar M. (2003) Systematics of earthworms from Jharkhand. III. Megascolecidae, Oikoassay, Vol.17, No. 2: 49-55.
  3. Sinha M., Srivastava R., Kumar M. and Singh MPN (2003) Laboratory observation on C/N ratio of soil by earthworm inoculation. Asian Jr. of Microbiol. Biotech. Env. Sc., Vol.5, No. (2): 87-89.
  4. Sinha M, Kumar M. and Srivastava R. (2001) Bioaccumulation of zinc in earthworm Perionyx sansibaricus and its impact on growth and metabolism. J. Ecophysiol. Occup. Hlth. 1: 265-274.
  5. Sinha M, Kumar M., Toppno R. S. and Srivastava R. (2001) Calorific changes in liver, ovary and muscle of hill stream fish Garramullya (sykes) due to cadmium toxicity. J. Ecophysiol. Occup. Hlth. 1: 375-384.

National Peer Reviewed Journals:

  1. Sinha M., Srivastava R., Gupta D.K. and Kumar M. (2003) Systematics of earthworms from Jharkhand. I. Moniligastridae, Proc. Zool. Soc. India. 2 (2): 15-20.
  2. Sinha M., Srivastava R., Kumar M. and Gupta D.K. (2003) Systematics of earthworms from Jharkhand. II. Octochaetidae and Ocnerodrilidae, Proc. Zool. Soc. India. 2 (2): 21-28.
  3. Sinha M., Srivastava R., Kumar M., Gupta D. K. and Sen N. S. (2003) Population biology and reproductive strategy of Ocnerodrilus occidentalis (Oligochaeta: Ocnerodrilidae) from tropical agroecosystem at Ranchi, Jharkhand, India. Trans. Zool. Soc.East. India, 7(2):33-41.
  4. Srivastava R., Kumar M., Choudahary A. K. and Sinha M.P. (2003) Earthworm diversity in Jharkhand state. Journal of Nature, Environment & Pollution Technology, Vol. 2(3):357-362.
  5. Sinha M., Srivastava R., Kumar M., Gupta D. K. and Swarnim K. (2003) Secondary production of the earthworm Perionyx sansibaricus (Michaelsen) in a garbage site at Ranchi, Jharkhand. Journal of Science and Techn.: Sambalpur University (SUJST), 1. Vol. XIV &XV(A):39-45.
  6. Kumar M. and Sinha M.P. (2003) Impact of copper accumulation on growth and secondary production of a megascolocid earthworm Perionyx sansibaricus (Michaelsen). Ranchi University Journal of Science and Technology (ROUJST). Vol. 1, No. 1: 5-8.
  7. Sinha M, Kumar M., Srivastava R. and Choudhary.A. (2002) Vermiculture biotechnology for pollution control. Nature Environment and Pollution Technology, 1(4): 401-405.
  8. Sinha M., Srivastava R Swarnim K. and Kumar M. (2002) Population density, biomass and secondary production of Ocnerodrilus occidentalis (Eisen) from a tropical cropland agroecosystem at Ranchi, Jharkhand, India. Proc. Zool. Soc. India. 1 (1& 2): 111-125.

Books chapters written:

Chapters Contributed to Edited Volume Published by National Level Publishers:

  1. Singh S. and Kumar M. (2023) Hairy Root Cultures: A Versatile Tool for Bioactive Compound Production. In N. Kumar, R. S. Singh (eds.), Biosynthesis of Bioactive Compounds in Medicinal and Aromatic Plants, Food Bioactive Ingredients. Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-35221-8_7
  2. Afreen U, Kumar M, Mukhopadhyay K (2023) Small RNA networking: host-microbe interaction in food crops. In: Guleria P., Kumar V and Mo Beixin (ed.) Plant Small RNA in Food Crops. ELSEVIER BV. DOI: 10.1016/B978-0-323-91722-3.00017-8.
  3. Dutta S, Afreen U, Kumar M, Mukhopadhyay K (2020) Small RNA in tolerating various biotic stresses. In: Guleria P and Kumar V (ed.) Plant Small RNA, 1st Edition, Biogenesis, Regulation and Application. ELSEVIER BV. Publishing Date: 1st February 2020. DOI: 10.1016/B978-0-12-817112-7.00008-0
  4. Singh S., Banerjee M., Kumar M. (2017) An Efficient Protocol for Plant Regeneration of Phlogacanthus thyrsiflorus Nees: An Important Medicinal Shrub. In: Mukhopadhyay K., Sachan A., Kumar M. (eds) Applications of Biotechnology for Sustainable Development. Springer, Singapore. DOI 10.1007/978-981-10-5538-6_3. ISBN 978-981-10-5537-9
  5. Sarkar B, Kumar M., and MukhopadhyayK.(2017) A Rapid Method for Detection and Characterization of Anthocyanins from Hibiscus, Ocimum and Syzygium Species and Evaluation of Their Antioxidant Potential.In: Mukhopadhyay K., Sachan A., Kumar M. (eds) Applications of Biotechnology for Sustainable Development. Springer, Singapore. 10.1007/978-981-10-5538-6_16. ISBN 978-981-10-5537-9
  6. Bioinformatics Analysis of Triticum aestivum L. WRKY1B Protein. In: Biotechnology for People.pp.168-172, 2013,ISBN:978-9380663-86-9
  7. Interspecific competitive inhibition of respiration among some earthworms in laboratory experiment. In: Biodiversity Conservation, Environmental Pollution and Ecology – APH Publishing House. pp. 197-204, 2002.
  8. Diurnal variation in soil respiration in tropical deciduous forest and pasture ecosystems. In: Biodiversity Conservation, Environmental Pollution and Ecology - APH Publishing House. pp. 181-190, 2002.
  9. Ecotaxonomy and Biomonitoring of lake for conservation and management. I. Abiotic Profile. In A. Kumar (Ed.) ‘Ecology & conservation of Lakes, Reservoir and Rivers’. Oxford Publishers, Jaipur, pp- 248-289, 2002.
  10. Ecotaxonomy and Biomonitoring of lake for conservation and management. II. Biotic Profile. In A. Kumar (Ed.) ‘Ecology & conservation of Lakes, Reservoir and Rivers’. Oxford Publishers, Jaipur. pp- 290-349 2002.
  11. Bioaccumulation of zinc in a megascolocid earthworm Perionyx sansibaricus (Michaelsen) and its impact on growth and secondary production.  Contributions to BIOSCIENSES (Eds. B. N. Pandey and P. S. Murthy, Published by Zoological Society of India. Pp 189-201, 2003.

Books: Mukhopadhyay K., Sachan A., Kumar M. (eds) Applications of Biotechnology for Sustainable Development. Springer, Singapore. DOI 10.1007/978-981-10-5538-6_3. ISBN 978-981-10-5537-9.

 
  Member of Professional Bodies
 
  • Life membership of Zoological Society of India, (M-14/2004)
  • Life Membership of Association of Microbiologist of India, (AMI 2153/2007)
  • Life Member of Indian Society of Technical Education, (70005/2010)
  Current Sponsored Projects
 
Title of Project Sponsoring Agency Year (From-to) Fund Value Status

Unraveling the roles of wheat and Puccinia triticina microRNAs through Dual RNA-sequencing during leaf rust infection and characterization of microRNA–encoded peptides associated in the process.

(CRG/2023/006836)		 DST-SERB 03.06.2024- 02.06.2027  40.42 Lakhs Ongoing
Development of Micro-Encapsulated Streptococcus salivarius K12 and Curcumin Extract Gel and Its Effect on Oral Mucositis in Oral Cancer Patients DST-SERB 16.10.2024 – 15.10.2027 

30.73 Lakhs

(BIT Share-12.65 Lakhs)		 Ongoing

Development of recombinant human Growth Colony Stimulating Factor

File No.- 40-186/2011 (SR)		 UGC 01.07.2011 -31.03.2015 13.67 Lakhs Completed
Discovery, annotation, validation and characterization of SNPs in Wheat (Triticum aestivum L.) and haplotype structure determination using Next-Generation Sequencing Data (File No.- BT/PR3925/BID/7/ 384/2011) Department of Biotechnology, Govt. of India 01.06.2012 -31.12.2015

49.8 Lakhs

(BIT share -24.6 L)		 Completed
Identification and Molecular Characterization of SNARE Genes in Wheat (Triticum aestivum L.) in Response to Leaf Rust Disease DST-SERB 06.02.2017-05.05.2020 34.67 Lakhs Completed
  Text and Reference Books
 
  1. Applications of Biotechnology for Sustainable Development. Springer, Singapore. DOI 10.1007/978-981-10-5538-6. ISBN 978-981-10-5537-9. Mukhopadhyay K., Sachan A., Kumar M. (eds)
  Fellow
 
  1.  Fellow of Zoological Society of India