Dr. Sneha Singh has been an Assistant Professor in the Department of Bioengineering at Birla Institute of Technology, Mesra, Ranchi, India, since 2016. She received her PhD (Technology) in the domain of Nanobiotechnology, from the Birla Institute of Technology, Mesra, in 2015. Her research interests span Nanobiotechnology, Functional Biomaterials, Phytomedicines, Antimicrobials & Tissue Engineering Regenerative medicine. Her lab focuses on developing different nanomaterials, phytobioactives, and smart biomaterials for biomedical applications.  They have optimized the fabrication of functionalized organic and inorganic nanomaterials for various applications, including infection control,nano-theranostic and tissue engineering. In addition, they also explore bioprospecting and phytobioactives for biotechnological and therapeutic applications. The lab focuses on developing new generation smart biomaterials, including stimuli-responsive polymers, composites and ceramics functionalized with phytobioactives and nanomaterials for tissue engineering and regenerative medicines while conducting active research collaborations with nationally and internationally renowned institutes of eminence.

Nanomaterials, Drug delivery, Phytobioactives, Antimicrobials, Functional Biomaterials, Tissue engineering & Regenerative Medicine

• Awarded “Distinguished Research Contribution” for research publication in highest impact journal (IF 15.15) by Birla Institute of Technology Mesra, Aug 2023.
• Chaired technical session at International Online Conference on Materials Science and Technology (ICMT), 2021 By Mahatma Gandhi University Kottayam, Kerala, India
• Invited talk on "Nanoparticles as Multimodal Tool for Biomedical Applications" at International Online Conference on Materials Science and Technology (ICMT), 2021 By Mahatma Gandhi University Kottayam, Kerala, India.
• Invitee for Japan-Asia Youth exchange program in Science (2017) By Japan Science & Technology, Japan.
• Invited speaker in Two-week workshop on Alternate Fuel and Engineering Materials, January 24, 2011, at Indian Railways Institute of Mechanical and Electrical Engineering (IRIMEE), Jamalpur, Bihar, to lecture on "Nanocomposite: In application to Indian Railways".

Journal Publication:

1. Gupta, A., Madhyastha, H., Kumar, A., & Singh, S*. (2024). Osteo-modulatory potential of biologically synthesized cis-resveratrol passivated gold nanoparticles . International Journal of Pharmaceutics, 124637. [IF=5.3] (SCI) (Q1)
2. Dwivedi, A., Das, S., Tiwari, V., Yadav, V., Jain, S. K., Mandal, V., …, Singh, S., ... Patra, A. (2024). Microwave-assisted green synthesis of silver nanoparticles using Mitragyna parvifolia bark extract and their biological activities: an economical and environment-friendly approach. Green Chemistry Letters and Reviews, 17(1). [IF=6.6] (SCIE) (Q1)
3. Gupta, A., Mehta, S. K., Qayoom, I., Gupta, S., Singh, S*., & Kumar, A. (2023). Biofunctionalization with Cissus quadrangularis Phytobioactives Accentuates Nano-Hydroxyapatite Based Ceramic Nano-Cement for Neo-Bone Formation in Critical Sized Bone Defect. International Journal of Pharmaceutics, 123110. [IF=5.3] (SCI) (Q1)
4. Gupta, S., Qayoom, I., Gupta, P., Gupta, A., Singh, P., Singh, S., & Kumar, A. (2023). Exosome-Functionalized, Drug-Laden Bone Substitute along with an Antioxidant Herbal Membrane for Bone and Periosteum Regeneration in Bone Sarcoma. ACS Applied Materials & Interfaces, 15, 8824−8839. [IF=8.3] (SCI) (Q1)
5. Gupta, A., Mehta, S. K., Kumar, A., & Singh, S*. (2023). Advent of Phytobiologics and Nano-Interventions for Bone Remodeling: A Comprehensive Review. Critical Reviews in Biotechnology, 1-28. [IF=9.0] (SCI) (Q1)
6. Paliwal, S., Jana, P., Singh, S., Madhyastha, H., Webster, T. J., & Dev, A. (2022). Folic acid conjugated capecitabine capped green synthesized fluorescent carbon dots as a targeted nano-delivery system for colorectal cancer. Materials Today Communications, 33, 104590. [IF=3.8] (SCIE)
7. Gupta, A., & Singh, S*. (2022). Multimodal Potentials of Gold Nanoparticles for Bone Tissue Engineering and Regenerative Medicine: Avenues & Prospects. Small, 18, 2201462. [IF=13.3] (SCI)
8. Kumari, G., Abhishek, K., Singh, S., Hussain, A., Altamimi, M. A., Madhyastha, H., Webster, T. J., & Dev, A. (2022). A voyage from 3D to 4D printing in nanomedicine and healthcare: part II. Nanomedicine, 17, 255-270. [IF=6.6] (SCIE)
9. Kumari, G., Abhishek, K., Singh, S., Hussain, A., Altamimi, M. A., Madhyastha, H., Webster, T. J., & Dev, A. (2022). A voyage from 3D to 4D printing in nanomedicine and healthcare: part I. Nanomedicine, 17, 237-253. [IF=6.6] (SCIE)
10. Gupta, A., Mehta, S. K., Kumar, A., & Singh, S*. (2023). Advent of Phytobiologics and Nano-Interventions for Bone Remodeling: A Comprehensive Review. Critical Reviews in Biotechnology, 43, 142-169. [IF=9.5] (SCI)
11. Jana, P., Shyam, M., Singh, S., Jayaprakash, V., & Dev, A. (2020). Biodegradable Polymers in Drug Delivery and Oral Vaccination. European Polymer Journal, 142, 110155. [IF=5.546] (SCIE)
12. Singh, P., Gupta, A., Qayoom, I., Singh, S., & Kumar, A. (2020). Orthobiologics with phytobioactive cues: A paradigm in bone regeneration. Biomedicine & Pharmacotherapy, 130, 110754.  [IF=7.5] (SCI)
13. Gupta, A., Padmanabhan, P., & Singh, S*. (2020). Resveratrol isomeric switching during bioreduction of gold nanoparticles: a gateway for cis-resveratrol.  Nanotechnology, 31, 465603. [IF=3.5] (SCIE) 
14. Madhyastha, H., Madhyastha, R., Thakur, A., Kentaro, S., Dev, A., Singh, S., Chandrashekharappa, B., Kumar, H., Acevedo, O., Nakajima, Y., Daima, H. K., Aradhya, A., Nagaraj N., & Maruyama, M. (2020). c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism. Colloids and Surfaces B: Biointerfaces,194, 111211. [IF=5.8] (SCIE) 
15. Singh, S*., Gupta, A., Qayoom, I., Teotia, A. K., Gupta, S., Padmanabhan, P., Dev, A., & Kumar, A. (2020). Biofabrication of Gold Nanoparticles with Bone Remodelling Potential: An In-vitro and In-vivo Assessment. Journal of Nanoparticle Research, 22, 152. [IF=2.5] (SCIE) 
16. Qayoom, I., Teotia, A. K., Meena, M., Singh, P., Mishra, A., Singh, S., & Kumar, A. (2020). Enhanced bone mineralization using Withania somnifera incorporated hydroxyapatite based ceramic bone substitutes. Biomedical Materials, 15, 055015. [IF=4.0] (SCI)
17. Mallick, A., Gupta, A., Hussain, A., Aparajay, P., Singh, S., Singh, S. K., & Dev, A. (2020). Intranasal delivery of gabapentin loaded optimized nanoemulsion for augmented permeation. Journal of Drug Delivery Science and Technology, 56, 101606. [IF=5.0] (SCIE) 
18. Singh, S*., Dev, A., Gupta, A., Nigam, V. K., & Poluri, K. M. (2019). Nitrate Reductase mediated synthesis of surface passivated nanogold as broad-spectrum antibacterial agent. Gold Bulletin, 52, 197-216. [IF=2.2] (SCIE)
19. Singh, S*., Vidyarthi, A. S., Nigam, V. K., & Dev, A. (2014). Extracellular facile biosynthesis, characterization and stability of gold nanoparticles by Bacillus licheniformis. Artificial cells, nanomedicine, and biotechnology, 42, 6-12. [IF=6.3] (SCI)
20. Gupta, R., Singh, S., & Mukherjee, K., (2014). In silico characterization of nitrate reductase involved in gold nanoparticles synthesis in Pseudomonas denitrificans. International Journal of Pharma and Bio Sciences, 5, 376-388. 
21. Kumar, A., Sharma, N., Singh, S., Sasmal, D., & Dev, A. (2014). Oral vaccine antigen induced immune response signalling pathways: current and future perspectives. Journal of Vaccines and Vaccination, 5, 1-6. 
22. Tikariha, S., Singh, S., Banerjee, S., & Vidyarthi, A. S. (2012). Biosynthesis of gold nanoparticles, scope and application: a review. International Journal of Pharmaceutical Sciences and Research, 3, 1603-1615. ESCI
23. Dev, A., Gupta, R. N., & Singh, S. (2012). Controlled release study of cell envelope proteins of Vibrio cholerae from alginate/HPMC microcapsule. European Journal of Experimental Biology, 2, 114-121.
24. Banerjee, S., Singh, S., Tikariha, S. and Vidyarthi, A. S. (2011). A review on biological synthesis of gold nanoparticles and its applications. Pharmbit 23&24, 11-17.

Book Chapters:

1. Gupta, A., Deka, R., Mehta, S. K., Kunal, K., & Singh, S*. (2024). Modulatory Effects of Phytobioactives in Bone Metabolism and Regeneration. In Emerging Materials and Technologies for Bone Repair and Regeneration (pp. 216-243). CRC Press.
2. Gupta, A., Mehta, S. K., Kunal, K., Mukhopadhyay, K., & Singh, S*. (2022). Quantum dots as promising nanomaterials in agriculture. In S. Ghosh, S. Thongmee and A. Kumar (Eds.) Agricultural Nanobiotechnology: Biogenic Nanoparticles, Nanofertilizers and Nanoscale Biocontrol Agents. Cambridge, U.S: Elsevier. ISBN: 978-0-323-91908-1
3. Gupta, A., Dev, A., Nigam, V. K., Padmanabhan, P., & Singh, S*. (2020). A Review on Next-Generation Nano-Antimicrobials in Orthopedics: Prospects and Concern. In R. Prasad, B. Siddhardha and M. Dyavaiah (Eds.) Nanostructures for Antimicrobial and Antibiofilm applications. Cham, Switzerland: Springer Nature. ISBN: 978-303-04-0336-2
4. Gupta, A., Padmanabhan, P., & Singh, S*. (2020). Bionanocomposites: Green Materials for Orthopedic Applications. In S. E. Jujjavarapu and K. M. Poluri (Eds.) Green Polymeric Nanocomposites., Boca Raton, Florida, USA: CRC Press. ISBN: 978-113-84-8657-7
5. Gupta, A., Aparajay, P., Shree, V., Das, S. S., Singh, S., & Dev, A. (2020). Potential Treatment Strategies for the Management of Cholera: A Review. In L. V. Berhardt (Ed.) Vibrio cholerae: Characteristics, Pathogenesis and Evolution. New York, USA: Nova Science. ISBN: 9781536171853
6. Tikariha, S., Banerjee, S., Dev, A., & Singh, S*. (2017). Growth phase-dependent synthesis of gold nanoparticles using Bacillus Licheniformis. In K. Mukhopadhyay, A. Sachan and M. Kumar (Eds.) Applications of Biotechnology for Sustainable Development. Singapore: Springer. ISBN: 978-981-10-5537-9
7. Singh, S*., Vidyarthi, A. S., Dev, A. (2015). Microbial synthesis of nanoparticles: An Overview. In O. V. Singh (Ed.) Bio-Nanoparticles: Biosynthesis and Sustainable Biotechnological Implications, USA: John Wiley & Sons. ISBN: 978-1-118-67768-1

Conference Publication

1. Rawat V., Mukhopadhyay K., Singh S*. Prospecting the influence of selenium nanoparticles on wheat plant growth and bioactivity. In International Conference on Fungal Biology and Plant Microbe Interactions (ICFBPMI-2024), Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, UP, India. February 16-18, 2024. 
2. Yadav N., Singh S*. Nanocarrier mediated on-site delivery of phytobioactive cues for therapeutic applications. In International Conference on Fungal Biology and Plant Microbe Interactions (ICFBPMI-2024), Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, UP, India. February 16-18, 2024. 
3. Mehta S.K., Kumar A., Singh S*. Advanced nanocomposite for controlling bone infections. In International Conference on Exploring New Horizons in Biotechnology (ENB-2023), Institute of Science, Banaras Hindu University, Varanasi, UP, India. February 10-12, 2023.
4. Kunal K., Singh S*. Selenium Nanoparticles as a potent antimicrobial agent. In International Conference on Exploring New Horizon in Biotechnology (ENB-2023), Institute of Science, Banaras Hindu University, Varanasi, UP, India. February 10-12, 2023.
5. Kunal K., Singh S*. Antibacterial activity of the synthesized nanoparticles against gram positive and gram negative bacteria. In International Conference on Recent Advances in Biotechnology, icRAB -2022, Dr. B R Ambedkar National Institute of Technology Jalandhar, India. December 2-4, 2022.
6. Gupta A., Singh S*. Unravelling the green synthesis strategies of gold nanoparticles for isomeric stabilization of resveratrol. In 2nd Indo-Korea Virtual Conference on Development of Advanced Materials for Future Technologies (DAMFT - 2021), Vellore Institute of Technology (VIT) Chennai, Tamil Nadu, India and KAIST, Daejeon, South Korea. May 14-15, 2021.
7. Deka R., Singh S., Jain A. Virtual Screening, Drug Likeness and Toxicity Study of Molecules Targeting Surface Receptor of Osteosarcoma Cells. In International Conference on Infectious Diseases and Immunopathology, IDIP 2021, Savitribai Phule Pune University, Pune, India. April 22-24, 2021.
8. Frozan F., Singh S., Jain A. In Silico Evaluation of Natural Products for Therapeutics Application for Osteoporosis. In International e-Conference on Covid-19: Challenges and Opportunities in Pharmaceutical Research, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat, India and Indrashil University, Mahesana, Gujarat, India. March 18-19, 2021.
9. Chakka A., Singh S., Jain A. Screening of New Compounds for Artificial Bone Regeneration: A Computational Approach. In International e-Conference on Covid-19: Challenges and Opportunities in Pharmaceutical Research, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat, India and Indrashil University, Mahesana, Gujarat, India. March 18-19, 2021.
10. Falak S., Nigam V. K., Gupta A., Singh S*. Synthesis and characterization of multifunctional herbal nanoconjugate for biomedical application. In International Conference on Global Challenges in Nanomaterials Research for Environmental and Healthcare Application, NREHA 2020, CSIR Institute of Mineral and Material technology, Bhubaneswar, India. March 19-20, 2020.
11. Kunal K., Gupta A., Padmanabhan P., Singh S*. Enhanced antioxidant activity of curcumin nanofibers. In All India Student’s Conclave and National Seminar, SPIRIT’20, Pharmaceutical Engineering and Technology, IIT (BHU), Varanasi, India. 2020.
12. Kunal K., Gupta A., Padmanabhan P., Singh S*. Optimization and Fabrication of nanofibers for biomedical application. In International Conference on Global Challenges in Nanomaterials Research for Environmental and Healthcare Applications, NREHA 2020, CSIR Institute of Mineral and Material Technology, Bhubaneswar, India. March 19-20, 2020.
13. Shree A., Gupta A., Singh S*. Synthesis and characterization of functional composite nanofibres from Cissus Quadrangularis, In International Conference on Global Challenges in Nanomaterials Research for Environmental and Healthcare Applications, NREHA 2020, CSIR Institute of Mineral and Material Technology, Bhubaneswar, Orissa, India. March 19-20, 2020.
14. Gupta A., Padmanabhan P., Kumar A., Singh S*. Biogenic Synthesis of Resveratrol Mediated Gold Nanoparticles and its Biological Activities. In International Conference on Biomaterial-based Therapeutic Engineering and Regenerative Medicine (BioTERM), IIT Kanpur, Kanpur, Uttar Pradesh, India. Nov 28 - Dec 1, 2019.
15. Singh S*., Dev A., Nigam V. Facile Synthesis of Stable Biogenic Gold nanodots with potential antimicrobial activity". In The 6th Asian Biomaterials congress (6th ABMC), Thiruvananthapuram, Kerala, India. Oct 25-27, 2017.
16. Gupta R., Singh S., Mukherjee K. A comparative codon usage biasness study of Pseudomonas denitrificans and Pseudomonas aeuroginosa involved in gold nanoparticles synthesis. In International Conference on Health, Environment & Industrial Biotechnology (Biosangam), Allahabad, Uttar Pradesh, India. Nov 21-23, 2013.
17. Singh S*., Vidyarthi A. S, Banerjee S., Tikariha S. Biosynthesis of gold nanoparticles using Bacillus licheniformis. In AMI 51st Annual conference on International Symposium on Recent Advances in Cross-disciplinary Microbiology: Avenues & Challenges, BIT Mesra, Ranchi, Jharkhand. Dec 14-17, 2010.
18. Dev A., Singh S. Vaccination with recombinant immunodominant protein: A composite approach for the treatment of multiple drug resistance (MDR) in tuberculosis. In National Conference on Application of Biotechnology & Development of Bihar, BIT Patna Campus, Patna, Bihar. March 22-24, 2010.

1. Life Member of Society for Biomaterials and Artificial Organs, India (SABOI)
2. Life Member of Biotechnology Research Society of Indian (BRSI)

Ongoing

• Self-fitting 4D-Printed Smart Scaffolds with Efficient Bone Regenerative Potential

Funding agency- SERB CRG {F. No. CRG/2021/002179}

Total Grant- Rs. 70,56,808/-

Duration- 2021-present

Completed

• Development of multi-functional nano-HAP bone substitute for effective bone regeneration in critical defects

Funding agency- DST Nanomission, GOI {F. No. DST/NM/NT/2018/48(G)}

Total Grant- Rs. 1,13,25,480/-

Duration- 2019-2022

• Process Optimization for Gold Nanoparticle Production by Microorganisms Funding agency- University Grants Commission, GOI {F. No. 41-1336/2012(SR)} Duration- 2012-2014

Kumar, A., Singh, S., & Singh, P. (Eds.). (2024). Emerging Materials and Technologies for Bone Repair and Regeneration (1st ed.). CRC Press. https://doi.org/10.1201/9781003307310

• A Biocomposite Delivery System for Phytobioactives in Bone Healing. Application Number 202211024100 filed on April 19, 2023. Published (June, 2023).
• Nano-scaffold Loaded with trans-Resveratrol Stabilized Gold Nanoparticles for Enhanced Bone Regeneration and Applications Thereof. Application Number 202331031960 filed on May 4, 2023. Published (December, 2023).

Scientific Reports, Nature