Birla Institute of Technology, Mesra
Faculty Image

Dr. Ashoke Sharon

Joined Institute on : 15-Jan-2009

  • Professor and Dean of faculty affairs
  • Chemistry
  • M.Sc. Tech., Ph.D. (CSIR-CDRI, Lucknow), POST-DOC (USA)
Contact Address

A-27, Hariom City, Rudiya Road, Mesra, Ranchi, Jharkhand-835217.

A-27, Hariom City, Rudiya Road, Mesra, Ranchi, Jharkhand-835217.

  • Phone Office - 916512276531
  • Phone Residence - 9470959291
  • Email - asharon@bitmesra.ac.in
Work Experience

Teaching : 12 Years

Research : 16 Years
Professional Background

Academic & Research

  1. Ph.D. from CSIR-CDRI, Lucknow; Ph.D. Thesis Submission: July 2004; Awarded: June 2005.
  2. Postdoctoral Experience (Sep 2004 to Nov 2008), University of Georgia, USA: 4 Years 3 Months
  3. Assistant Professor, BIT Mesra: Jan 2009 to June 2011.
  4. Associate Professor, BIT Mesra: July 2011-Continue.
  5. Extramural Government Project Completed: 4 (UGC#1, SERB-DST#1, DBT#2)
  6. Ongoing Government Project: 1 (SERB-DST)
  7. Ongoing International Project: 1 (Kagoshima University, Japan) 2016- Continue.
  8. Consultancy Project Completed: 2
  9. Ongoing Consultancy: 1 (Dr. Reddy Lab, Hyderabad)
  10. Ph.D. Guided (Awarded): 8
  11. Ongoing Ph.D.: 3
  12. National Collaboration: 4
  13. International Collaboration: 2

Administrative

  1. Associate Dean, Student Welfare, BIT Mesra: July 2018-Continue. 
  2. Incharge, 400 MHz NMR Laboratory (DST FIST); 2016-Continue.
  3. Coordinator, Admission, BIT Mesra: 5 Years; 
  4. Cultural Coordinator, BIT Mesra: 4 Years
  5. Hostel Warden, BIT Mesra: 2 Years

Dr. Sharon Reseach Group WebPage
Research Areas
  • Organic & Medicinal Chemistry
  • Computational Chemistry & Molecular Modeling
  • Small Molecule X-Ray Crystallography and Drug Discovery
Award and Honours
Publications

Number of Publications (SCI INDEXED): 80

Citation: 1032

H-Index: 19

  1. Ansari, A. J.; Wani, A. A.; Maurya, A. K.; Verma, S.; Agnihotri, V. K.; Sharon, A.; Bharatam, P. V.; Sawant, D. M., An unprecedented N- to C-sulfonyl migration in the reaction of azomethine amine and allenoates: access to arylsulfonylmethyl substituted pyrazolo[1,5-c]quinazoline and mechanistic studies. Chemical Communications 2019, 55, 14825.
  2. Trivedi, J.; Parveen, A.; Rozy, F.; Mitra, A.; Bal, C.; Mitra, D.; Sharon, A., Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity. European journal of medicinal chemistry 2019, 183, 111699.
  3. Rozy, F.; Sharon, A., Base Catalyzed Scaffold Shift from Pyranone Carboxamide to Pyrazolyl Acetamide through Intramolecular Ring Transformation. ChemistrySelect 2019, 4 (20), 6194-6197.
  4. Chakravarty, H.; Bal, C.; Yadav, M.; Jena, N.; Bal, N. C.; Sharon, A., First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers. ACS Omega 2019, 4 (7), 11508-11514.
  5. Joshi, G.; Chauhan, M.; Kumar, R.; Thakur, A.; Sharma, S.; Singh, R.; Wani, A. A.; Sharon, A.; Bharatam, P. V.; Kumar, R., Cyclocondensation reactions of an electron deactivated 2-aminophenyl tethered imidazole with mono/1,2-biselectrophiles: synthesis and DFT studies on the rationalisation of imidazo[1,2-a]quinoxaline versus benzo[f]imidazo[1,5-a][1,3,5]triazepine selectivity switches. Organic Chemistry Frontiers 2018, 5 (24), 3526-3533.
  6. Kundu, S.; Kumari, N.; Soni, S. R.; Ranjan, S.; Kumar, R.; Sharon, A.; Ghosh, A., Enhanced Solubility of Telmisartan Phthalic Acid Cocrystals within the pH Range of a Systemic Absorption Site. ACS Omega 2018, 3 (11), 15380-15388.
  7. Pathare, R. S.; Ansari, A. J.; Verma, S.; Maurya, A.; Maurya, A. K.; Agnihotri, V. K.; Sharon, A.; Pardasani, R. T.; Sawant, D. M., Sequential Pd(0)/Fe(III) Catalyzed Azide-Isocyanide Coupling/Cyclization Reaction: One-Pot Synthesis of Aminotetrazoles. J Org Chem 2018, 83 (16), 9530-9537.
  8. Pathare, R. S.; Patil, V.; Kaur, H.; Maurya, A. K.; Agnihotri, V. K.; Khan, S.; Devunuri, N.; Sharon, A.; Sawant, D. M., Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates. Org Biomol Chem 2018, 16 (37), 6885-6888.
  9. Pathare, R. S.; Sharma, S.; Elagandhula, S.; Saini, V.; Sawant, D. M.; Yadav, M.; Sharon, A.; Khan, S.; Pardasani, R. T., Application of Isocyanides as Amide Surrogates in the Synthesis of Diverse Isoindolin-1-one Derivatives by a Palladium-Catalyzed Tandem Carboxamidation/Hydroamidation Reaction. European Journal of Organic Chemistry, 2016, 5579-87.
  10. Mohan Kasula, M.; Toyama, M.; Samunuri, R.; Rozy, F.; Yadav, M.; Bal, C. Jha, A. K.; Baba, M.; Sharon, A.; Synthesis and anti-HBV activity of α-stereoisomer of aristeromycin based analogs Bioorganic Medicinal Chemistry Letters 2016, 25, 5224-7.
  11. Thiyagarajan, A.; Toyama, M.; Baba, M.  Sharon, A.; Bal, C. Synthesis and Anti-HCV Activity of 4-Methoxy-7H-Pyrrolo[2,3-d] Pyrimidine Carbocyclic. Nucleosides, Nucleotides and Nucleic Acids, 2016, 35, 305-14.
  12. Kasula, M., Samunuri, R.; Chakravarty, H.; Bal, C.; Baba, M.; Jha, A. K.; Sharon, A.; Regioselective synthesis of pyrazolo[3,4-d]pyrimidine based carbocyclic nucleosides as possible antiviral agent. Nucleosides, Nucleotides and Nucleic Acids, 2016, 35, 43-52.
  13. Chaudhary, S.; Sharma, V.; Jaiswal, P. K.; Gaikwad, A. N.; Sinha, S. K.; Puri, S. K.; Sharon, A.; Maulik, P. R.; Chaturvedi, V. Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin. Org Lett 2015, 17, 4948-51.
  14. Balaraju, T.; Konreddy, A. K.; Parveen, A.; Toyama, M.; Ito, W.; Karampuri, S.; Baba, M.; Sharon, A.; Bal, C. Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold. Bioorg Med Chem Lett 2015, 25, 5224-7.
  15. Bal, N. C.; Jena, N.; Chakravarty, H.; Kumar, A.; Chi, M.; Balaraju, T.; Rawale, S. V.; Rawale, J. S.; Sharon, A.; Periasamy, M. The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin. Biopolymers 2015, 103, 15-22.
  16. Singh, S.; Yadav, P.; Sahu, S. N.; Sharon, A.; Kumar, B.; Ram, V. J.; Pratap, R.;  One pot chemoselective synthesis of arylated benzo[h]quinolines. Synlett 2014, 25, 2599-2604.
  17. Bag, P.; Ojha, D.; Mukherjee, H.; Halder, U. C.; Mondal, S.; Biswas, A.; Sharon,  A.; Kaer, L. V.; Chakrabarty, S.; Das, G.; Mitra, D.; Chattopadhyay, D. A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events, Antiviral Research, 2014, 105, 126-134.
  18. Karampuri, S.; Bag, P.; Chakravarty, H.; Bal, C.; Chattopadhyay, D.; Sharon,  A. Anti-HSV activity and mode of action study of α-pyrone carboxamides. RSC Adv., 2014, 4, 17354-63.
  19. Konreddy, A. K.; Toyama, M.; Ito, W.; Bal, C.; Baba, M.; Sharon, A. Synthesis and Anti-HCV Activity of 4-Hydroxyamino α-Pyranone Carboxamide Analogs. ACS Med. Chem. Lett., 2014, 5, 259-263.
  20. Parveen, A.; Chakraborty, A.; Konreddy, A. K.; Chakravarty, H.; Sharon, A.; Trivedi, V.; Bal, C. Skeletal hybridization and PfRIO-2 kinase modeling for synthesis of alpha-pyrone analogs as anti-malarial agent. Eur J Med Chem, 2013, 70, 607-12.
  21. Nag, S.; Chouhan, D. K.; Balaji, S. N.; Chakraborty, A.; Lhouvum, K.; Bal, C.; Sharon, A.; Trivedi, V. Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies. Medicinal Chemistry Research, 2013, 22, 4737-4744.
  22. Kumar, A.; Chakravarty, H.; Bal, N. C.; Balaraju, T.; Jena, N.; Misra, G.; Bal, C.; Pieroni, E.; Periasamy, M.; Sharon, A. Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization. Molecular Biosystems, 2013, 9, 1949-1957.
  23. Kasula, M.; Balaraju, T.; Toyama, M.; Thiyagarajan, A.; Bal, C.; Baba, M.; Sharon, A. A Conformational Mimetic Approach for the Synthesis of Carbocyclic Nucleosides as Anti-HCV Leads. ChemMedChem, 2013, 8, 1673-1680.
  24. Karak, M.; Bal, N. C.; Bal, C.; Sharon, A. Targeting peroxisome proliferator-activated receptor gamma for generation of antidiabetic drug. Current diabetes reviews, 2013, 9, 275-85.
  25. Chouhan, D. K.; Sharon, A.; Bal, C. Molecular and structural insight into plasmodium falciparum RIO2 kinase. Journal of Molecular Modeling, 2013, 19, 485-496.
  26. Balaraju, T.; Kumar, A.; Bal, C.; Chattopadhyay, D.; Jena, N.; Bal, N. C.; Sharon, A. Aromatic interaction profile to understand the molecular basis of raltegravir resistance. Structural Chemistry, 2013, 24, 1499-1512.
  27. Bag, P.; Ojha, D.; Mukherjee, H.; Halder, U. C.; Mondal, S.; Chandra, N. S.; Nandi, S.; Sharon, A.; Sarkar, M. C.; Chakrabarti, S.; Chattopadhyay, D. An Indole Alkaloid from a Tribal Folklore Inhibits Immediate Early Event in HSV-2 Infected Cells with Therapeutic Efficacy in Vaginally Infected Mice. Plos One, 2013, 8.
  28. Thiyagarajan, A.; Salim, M. T. A.; Balaraju, T.; Bal, C.; Baba, M.; Sharon, A. Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent. Bioorg. Med. Chem. Lett., 2012, 22, 7742-7747.
  29. Karampuri, S.; Bag, P.; Yasmin, S.; Chouhan, D. K.; Bal, C.; Mitra, D.; Chattopadhyay, D.; Sharon, A. Structure based molecular design, synthesis and biological evaluation of alpha-pyrone analogs as anti-HSV agent. Bioorg. Med. Chem. Lett., 2012, 22, 6261-6266.
  30. Debprasad, C.; Hemanta, M.; Paromita, B.; Durbadal, O.; Kumar, K. A.; Shanta, D.; Kumar, H. P.; Tapan, C.; Ashoke, S.; Sekhar, C. Inhibition of NO2, PGE(2), TNF-alpha, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. Evidence-Based Complementary and Alternative Medicine, 2012.
  31. Ganguly, S.; Vithlani, V. V.; Kesharwani, A. K.; Kuhu, R.; Baskar, L.; Mitramazumder, P.; Sharon, A.; Dev, A. Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs. Acta Pharmaceutica 2011, 61, 187-201.
  32. Gadthula, S.; Rawal, R. K.; Sharon, A.; Wu, D.; Korba, B.; Chu, C. K. Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro 2.4 hepta ne-5,6-diol against hepatitis C virus. Bioorganic & Medicinal Chemistry Letters 2011, 21, 3982-3985.
  33. Bal, N. C.; Jena, N.; Sopariwala, D.; Balaraju, T.; Shaikh, S.; Bal, C.; Sharon, A.; Gyorke, S.; Periasamy, M. Probing cationic selectivity of cardiac calsequestrin and its CPVT mutants. Biochemical Journal 2011, 435, 391-399.
  34. Rao, J. R.; Jha, A. K.; Rawal, R. K.; Sharon, A.; Day, C. W.; Barnard, D. L.; Smee, D. F.; Chu, C. K. (-)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu). Bioorganic & Medicinal Chemistry Letters 2010, 20, 2601-2604.
  35. Kim, Y. A.; Rawal, R. K.; Yoo, J.; Sharon, A.; Jha, A. K.; Chu, C. K.; Rais, R. H.; Al Safarjalani, O. N.; Naguib, F. N. M.; el Kouni, M. H. Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorganic & Medicinal Chemistry 2010, 18, 3403-3412.
  36. Karuppasamy, M.; Mahapatra, M.; Yabanoglu, S.; Ucar, G.; Sinha, B. N.; Basu, A.; Mishra, N.; Sharon, A.; Kulandaivelu, U.; Jayaprakash, V. Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies. Bioorganic & Medicinal Chemistry 2010, 18, 1875-1881.
  37. Bal, N. C.; Sharon, A.; Gupta, S. C.; Jena, N.; Shaikh, S.; Gyorke, S.; Periasamy, M. The Catecholaminergic Polymorphic Ventricular Tachycardia Mutation R33Q Disrupts the N-terminal Structural Motif That Regulates Reversible Calsequestrin Polymerization. Journal of Biological Chemistry 2010, 285, 17188-17196.
  38. Mishra, N.; Basu, A.; Jayaprakash, V.; Sharon, A.; Basu, M.; Patnaik, K. K. Structure based virtual screening of GSK-3 beta: Importance of protein flexibility and induced fit. Bioorganic & Medicinal Chemistry Letters 2009, 19, 5582-5585.
  39. Liang, Y.; Sharon, A.; Grier, J. P.; Rapp, K. L.; Schinazi, R. F.; Chu, C. K. 5 '-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): Synthesis, anti-HIV activity, cytotoxicity and stability studies. Bioorganic & Medicinal Chemistry 2009, 17, 1404-1409.
  40. Kim, H.-J.; Sharon, A.; Bal, C.; Wang, J.; Allu, M.; Huang, Z.; Murray, M. G.; Bassit, L.; Schinazi, R. F.; Korba, B.; Chu, C. K. Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro. Journal of Medicinal Chemistry 2009, 52, 206-213.
  41. Jha, A. K.; Sharon, A.; Rondla, R.; Chu, C. K. Regioselective synthesis of 3-deazacarbovir and its 3-deaza-adenosine analogues. Tetrahedron 2009, 65, 9362-9367.
  42. Sharon, A.; Chu, C. K. Understanding the molecular basis of HBV drug resistance by molecular modeling. Antiviral Research 2008, 80, 339-353.
  43. Liu, P.; Sharon, A.; Chu, C. K. Fluorinated nucleosides: Synthesis and biological implication. Journal of Fluorine Chemistry 2008, 129, 743-766.
  44. Kim, Y. A.; Sharon, A.; Chu, C. K.; Rais, R. H.; Al Safarjalani, O. N.; Naguib, F. N. M.; el Kouni, M. H. Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase. Journal of Medicinal Chemistry 2008, 51, 3934-3945.
  45. Narayanasamy, J.; Pullagurla, M. R.; Sharon, A.; Wang, J.; Schinazi, R. F.; Chu, C. K. Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs. Antiviral Research 2007, 75, 198-209.
  46. Kim, Y. A.; Sharon, A.; Chu, C. K.; Rais, R. H.; Al Safarjalani, O. N.; Naguib, F. N. M.; el Kouni, M. H. Synthesis, biological evaluation and molecular modeling studies of N-6-benzyladenosine analogues as potential anti-toxoplasma agents. Biochemical Pharmacology 2007, 73, 1558-1572.
  47. Singh, F. V.; Kumar, R.; Sharon, A.; Broder, C. K.; Howard, J. A. K.; Goel, A.; Maulik, P. R. Synthesis and X-ray structural studies of pyrimidin-2,4-dione and 2-thioxo-1H-pyrimidin-4-one bearing chloroethyl moiety. Journal of Molecular Structure 2006, 782, 55-59.
  48. Liu, P.; Sharon, A.; Chu, C. K. Enantiomeric synthesis of carbocyclic D-4'-C-methyl-ribonucleosides as potential antiviral agents. Tetrahedron-Asymmetry, 2006, 17, 3304-3314.
  49. Dixit, M.; Sharon, A.; Maulik, P. R.; Goel, A. A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers. Synlett 2006, 1497-1502.
  50. Sil, D.; Kumar, R.; Sharon, A.; Maulik, P. R.; Ram, V. J. Stereoselective alkenylation of a 1,3-disubstituted pyrazol-5-one through ring transformation of 2H-pyran-2-ones. Tetrahedron Letters 2005, 46, 3807-3809.
  51. Sharon, A.; Pratap, R.; Vatsyayan, R.; Maulik, P. R.; Roy, U.; Goel, A.; Ram, V. J. 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-gamma activators. Bioorganic & Medicinal Chemistry Letters 2005, 15, 3356-3360.
  52. Sharon, A.; Pratap, R.; Tripathi, B.; Srivastava, A. K.; Maulik, P. R.; Ram, V. J. Biaryls and heterobiaryls as alpha-glucosidase and protein tyrosine phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters 2005, 15, 1341-1344.
  53. Sharon, A.; Pratap, R.; Tiwari, P.; Srivastava, A.; Maulik, P. R.; Ram, V. J. Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles. Bioorganic & Medicinal Chemistry Letters 2005, 15, 2115-2117.
  54. Sharon, A.; Pratap, R.; Maulik, P. R.; Ram, V. J. Synthesis of annelated a aza-anthracenones and thieno 3,2-g aza-naphthalenones through ring transformation of 2H-pyran-2-one followed by photocyclization. Tetrahedron 2005, 61, 3781-3787.
  55. Pratap, R.; Sharon, A.; Maulik, P. R.; Ram, V. J. A one-pot synthesis of an annelated a aza-thieno 3,2-g -napthalenone through ring transformation followed by photocyclization. Tetrahedron Letters 2005, 46, 85-87.
  56. Goel, A.; Singh, F. V.; Sharon, A.; Maulik, P. R. Regioselective syntheses of functionalized 2-aminopyridines and 2-pyridinones through nucleophile-induced ring transformation reactions. Synlett 2005, 623-626.
  57. Sil, D.; Sharon, A.; Pratap, R.; Maulik, P. R.; Ram, V. J. Synthesis of benzocyclobutanes through ring transformation reactions of 2H-pyran-2-ones. Synlett 2004, 2163-2164.
  58. Sil, D.; Sharon, A.; Maulik, P. R.; Ram, V. J. A concise synthesis of highly functionalized alpha,beta-unsaturated gamma-butyrolactones through ring contraction of 2H-pyran-2-ones. Tetrahedron Letters 2004, 45, 6273-6276.
  59. Sil, D.; Sharon, A.; Maulik, P. R.; Ram, V. J. One-pot synthesis of cyclopentadienones through ring contraction of 2H-pyran-2-ones. Tetrahedron Letters 2004, 45, 6619-6621.
  60. Sharon, A.; Maulik, P. R.; Vithana, C.; Ohashi, Y.; Ram, V. J. Synthesis of biphenanthrenyls and role of C-H center dot center dot center dot X noncovalent interactions in conformational control. European Journal of Organic Chemistry 2004, 886-893.
  61. Sharon, A.; Maulik, P. R.; Roy, R.; Ram, V. J. An innovative approach to the synthesis of annelated a diaza-anthracenones through tandem cyclization. Tetrahedron Letters 2004, 45, 5815-5818.
  62. Goel, A.; Agarwal, N.; Singh, F. V.; Sharon, A.; Tiwari, P.; Dixit, M.; Pratap, R.; Srivastava, A. K.; Maulik, P. R.; Ram, V. J. Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-lH-pyrroles in SLM and STZ models. Bioorganic & Medicinal Chemistry Letters 2004, 14, 1089-1092.
  63. Farhanullah; Sharon, A.; Maulik, P. R.; Ram, V. J. Amberlyst 15 catalyzed synthesis of indole-pyrazole based tri(hetero)arylmethanes. Tetrahedron Letters 2004, 45, 5099-5102.
  64. Sharon, A.; Srivastava, T.; Katti, B. S.; Maulik, P. R. 2-(4-Chlorophenyl)-3-cyclohexylthiazolidin-4-one. Acta Crystallographica Section E-Structure Reports Online 2003, 59, O1239-O1240.
  65. Sharon, A.; Dixit, M.; Maulik, P. R.; Goel, A. Molecular modeling studies of acetophenone derivatives for obtaining suitable ligands as protein tyrosine phosphatase-1B (PTP-1B) inhibitor. Medicinal Chemistry Research 2003, 12, 255-255.
  66. Sarkhel, S.; Sharon, A.; Trivedi, V.; Maulik, P. R.; Singh, M. M.; Venugopalan, P.; Ray, S. Structure-based drug design: Synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo b oxepines as non-steroidal estrogens. Bioorganic & Medicinal Chemistry 2003, 11, 5025-5033.
  67. Dixit, M.; Sharon, A.; Maulik, P. R.; Srivastava, A. K.; Goel, A. Design and synthesis of 2,4-dialkoxy-acetophenones as protein tyrosine phosphatase-1B (PTP-1B) inhibitors. Medicinal Chemistry Research 2003, 12, 306-306.
  68. Chattopadhyay, S. K.; Kumar, T. R. S.; Maulik, P. R.; Srivastava, S.; Garga, A.; Sharon, A.; Negi, A. S.; Khanuja, S. P. S. Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana. Bioorganic & Medicinal Chemistry 2003, 11, 4945-4948.
  69. Avasthi, K.; Farooq, S. M.; Tewari, A. K.; Sharon, A.; Maulik, P. R. Intermolecular stacking in pyrazolo 3,4-d pyrimidine-based pentamethylene-linked flexible molecules. Acta Crystallographica Section C-Crystal Structure Communications 2003, 59, O42-O45.
  70. Avasthi, K.; Farooq, S. M.; Rawat, D. S.; Sharon, A.; Maulik, P. R. A stacked pyrazolo 3,4-d pyrimidine-based flexible molecule: the effect on stacking of a bulky isopropyl group in comparison with a methyl/ethyl group. Acta Crystallographica Section C-Crystal Structure Communications 2003, 59, O523-O524.
  71. Avasthi, K.; Bhagat, D.; Bal, C.; Sharon, A.; Yadav, U.; Maulik, P. R. Unusual molecular conformation in dissymmetric propylene-linker compounds containing pyrazolo 3,4-d pyrimidine and phthalimide moieties. Acta Crystallographica Section C-Crystal Structure Communications 2003, 59, O409-O412.
  72. Avasthi, K.; Bal, C.; Sharon, A.; Maulik, P. R. 4,6-bis(methylsulfanyl)-1-(4-phenoxy-butyl)-1H-pyrazolo 3,4-d pyrimidine. Acta Crystallographica Section C-Crystal Structure Communications 2003, 59, O494-O495.
  73. Tandon, V. K.; Sharon, A.; Bandichhor, R.; Maulik, P. R. 1,4-dichloro-1,4-diphenyl-2,3-diazabuta-1,3-diene. Acta Crystallographica Section E-Structure Reports Online 2002, 58, o869-o870.
  74. Ram, V. J.; Agarwal, N.; Sharon, A.; Maulik, P. R. An expeditious synthesis of imidazo 1,2-a pyridines through nucleophile induced rings transformation reactions of 6-aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles. Tetrahedron Letters 2002, 43, 307-310.
  75. Ram, V. J.; Agarwal, N.; Saxena, A. S.; Farhanullah; Sharon, A.; Maulik, P. R. Carbanion induced synthesis of annulated unsymmetrical biaryls through ring transformation of 2H-pyran-2-one. Journal of the Chemical Society-Perkin Transactions 1 2002, 1426-1437.
  76. Chattopadhyay, S. K.; Sharon, A.; Yadav, U.; Srivastava, S.; Mehta, V. K.; Maulik, P. R. A taxane diterpenoid from the heartwood of Taxus wallichiana. Acta Crystallographica Section E-Structure Reports Online 2002, 58, o154-o155.
  77. Avasthi, K.; Tewari, A.; Rawat, D. S.; Sharon, A.; Maulik, P. R. A stacked pyrazolo 3,4-d pyrimidine-based flexible molecule: the effect of a bulky benzyl group on intermolecular stacking in comparison with methyl and ethyl groups. Acta Crystallographica Section C-Crystal Structure Communications 2002, 58, o494-o495.
  78. Avasthi, K.; Rawat, D. S.; Chandra, T.; Sharon, A.; Maulik, P. R. Isomeric pyrazolo 3,4-d pyrimidine-based molecules: disappearance of dimerization due to interchanged substitutions. Acta Crystallographica Section C-Crystal Structure Communications 2002, 58, O311-O313.
  79. Avasthi, K.; Farooq, S. M.; Sharon, A.; Maulik, P. R. Disappearance of inter-and intramolecular stacking due to one-atom addition in 'propylene-linker' in a pyrazolo 3,4-d pyrimidine-based flexible molecule. Acta Crystallographica Section E-Structure Reports Online 2002, 58, o940-o941.
  80. Ram, V. J.; Srivastava, P.; Agarwal, N.; Sharon, A.; Maulik, P. R. One-pot synthesis of unsymmetrical biaryls from suitably functionalized 2H-pyran-2-ones through carbanion-induced ring-transformation reactions. Journal of the Chemical Society-Perkin Transactions 1 2001, 1953-1959.

 
Member of Professional Bodies
  • Member of International Society of Antiviral Research (ISAR).
  • Life Member of Indian Society of Chemists and Biologist (L.F. No.. 353/2003)
  • Life Member of Association of Microbiologist of India
  • Member, Americal Chemical Society (ACS).
Current Sponsored Projects

ONGOING PROJECTS:

  1. Synthesis and development of novel HSP90 inhibitors as potential anti-HIV candidate molecules and elucidation of their mechanism of inhibition. SERB-DST, DEC 2018 - DEC 2021. (25 Lacs)
  2. Development of Antivirals, (Funder By Kagoshima University, Japan), 2016- Continue (33 Lacs received)

 

COMPLETED PROJECTS:

  1. The target based discovery of carbocyclic nucleosides as an anti-HCV agent through computer assisted drug design and synthesis. (PI); SERB-DST SR/FT/CS-001/2009; Sep 07, 2009; 2009-2013; 17.03 Lacs. 
  2. Computer assisted design and synthesis of carbocyclic nucleosides as an anti-hepatitis agent. (PI) UGC, F.No.37-110/2009 (SR); Dec 19, 2009; 2010-2013; 5.94 Lacs.
  3. Structure Based Discovery of novel antiviral molecules with potential to inhibit drug resistance viruses. (PI); Multi-Institutional Project (BIT-NCCS-ICMR) DBT BT/PR14237/MED/29/196/2010; OCT, 2010 2010-2014; 25.00 Lacs.
  4. Deciphering the mode of antiviral action of isolated phytoconstituents and their synthetic analogues/counterparts combining structure and analogs-based approach to develop a therapeutic anti-viral candidate. (PI) Multi-Institutional Project (BIT- ICMR); DBT BT/PR13759/PBD/17/686/2010; NOV 19, 2010; 2010-2014; 11.55 Lacs.
Text and Reference Books

BOOK CHAPTERS:

  1. Jena, N.; Bal, C.; Sharon, Ashoke, Plant and marine products: a promising hope in the search of therapeutics against dengue. In Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases, Elsevier: 2019; pp 385-405.
  2. Ashoke Sharon, A. Jha, C. K. Chu. “Chapter 16: Current Status of Anti-HBV Agents” Analogues Based Drug Discovery II, Edited by Janos Fischer and C. Robin Ganellin; Publisher: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim; ISBN: 978-3-527-32549-8. 2010.
  3. G. Sen, Ashoke Sharon, S. Pal. “Grafted Polysaccharides: Smart Materials of the Future. Their Synthesis and Applications” (Chapter-5) Biopolymers: Biomedical and Environmental Applications, , Publisher: Wiley- Scrivener Publishing, ISBN: 978-0-470-63923-8, 2011
Intellectual Property Rights (IPR)
  1. Novel pyranone carboxamide derivative and use thereof as Anti-Hepatitis C Virus drug, Masanori Baba, Ashoke Sharon, Chandralata Bal, and Ananda K Konreddy; Publication No: WO/2015/008779, Application No: PCT/JP2014/068880, Priority Date: July 17, 2013. Publication Date:Jan 22 2015. 
  2. Anti-hepatitis B virus drugs,  Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula,Japanese Patent Application number: JP 2013-254236, Filing date:   Dec. 9, 2013. [publication number: JP 2015-113285 (P2015-113285A) [publication date] June 22, 2015.
  3. Anti-hepatitis B virus drugs,  Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula,Japanese Patent Application number:  JP 2013-254238, Filing date: Dec. 9, 2013
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