Birla Institute of Technology, Mesra
Krishna Mohan Medicherla
Professor and Head, Bioengineering and Biotechnology
Ph.D.
Contact Address
Permanent Address G 6 Kasu Apartments, Old Airport Road New Bowenpally, Secundrabad -500011
Local Address F 3 Sri Ram Apartments, Gandhi Path, Vaishali Nagar, Jaipur - 302021
Phone (Office) 91-141-2227087
Phone Residence 91-9314509942
Email Id kmohan@bitmesra.ac.in
Joined Institute on : 2-Aug-2009

  Work Experience
 
Teaching : 14 Years

Research : 35 Years

Individual: 35 Years

  Professional Background

[1] Professor (August, 2009–till date), Department of Bioengineering & Biotechnology, Birla Institute of Technology, Mesra, (Jaipur Campus)

[2] Head, Research& Development (1997–till date), Biotechnology & Bioinformatics, Birla Institute of Scientific Research, Jaipur

[3] Fellow, Microbial Biotechnology (1992–1997), Tata Energy Research Institute, Habitat Place Lodhi Road, New Delhi, 110003

[4] Area Convener, Microbial Biotechnology (1990-1992), Tata Energy Research Institute, Habitat Place Lodhi Road, New Delhi, 110003.

[5] Research Associate, Microbial Biotechnology (1987-1990), Tata Energy Research Institute, Habitat Place Lodhi Road, New Delhi, 110003

[6] Senior Research Fellow (1981-1984), DAE Project, Department of Microbiology, College of Basic Sciences & Humanities, G B Pant University of Agriculture & Technology, Pantnagar, Uttarkhand.

  Research Areas
 

Microbial Technology, Medical Genomics

  Award and Honours
 
  • V Agnihotrudu Memorial, Award by Mycological Society of India, November, 2017
  Publications
 
  1. Towards Understanding the Key Signature Pathways Associated from Differentially Expressed Gene Analysis in an Indian Prostate Cancer Cohort. Submitted.  
  2. Metagenomic analysis of heavy metal?contaminated soils reveals distinct clades with adaptive features. 2022. International Journal of Environmental Science and Technology. https://doi.org/10.1007/s13762-022-04635-5
  3. Laccases as Gold Standard Enzymes for Biotechnology. 2022. Current Biotechnology, 2022, 11, 174-188. DOI: 10.2174/2211550111666220826102014
  4. Inferring bona fide differentially expressed genes and their variants associated with vitamin K deficiency using systems genetics approach. 2022. Genes, 13(11), 2078; doi:10.3390/genes13112078
  5. Diabetes mellitus susceptibility with varied diseased phenotypes and its comparison with phenome interactome networks. 2022. World J Clin Cases 2022 April 13;
  6. Monitoring of SARS-CoV-2 variants by wastewater-based surveillance as
    a sustainable & pragmatic approach- a case study of Jaipur (India). 2022. Water; Volume 14, Issue 3: 297 (February-1 2022). doi:10.3390/w14030297.
  7. Vitamin K in human health and metabolism: A nutri-genomics review, 2022. Trends in Food Science & amp; Technology, Volume 119, Pages 412-427.
  8. Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings from the INDIGENIUS Consortium. Frontiers in Endocrinology, section Clinical Diabetes. 14 April, 2022. https://doi.org/10.3389/fendo.2022.847692
  9. Metagenomic survey reveals more diverse and abundant antibiotic resistance genes in municipal wastewater than hospital wastewater . Frontiers in Microbiology (2021), 12: 1-9.
  10. Extraction of DNA and RNA from Formalin-Fixed Paraffin-Embedded Tissue Specimens”  Bio-101: e4095. (2021) DOI: 10.21769/BioProtoc.4095
  11. The Omic Insights on Unfolding Saga of COVID-19. Front. Immunol. (2021) 12:724914. doi: 10.3389/fimmu.2021.724914
  12. Comparative study of synonymous codon usage in bacteria growing at extreme temperatures (2021) International Journal of Bioinformatics Research and Applications, Vol.17 No.1, pp.53 - 68, DOI: https://doi.org/10.1504/IJBRA.2021.113966.
  13. Whole Exome Sequencing of Prostate Cancer in Indian Phenotype Reveals Distinct Polymorphisms”. Front Genet. 2020; 11:874. Published 2020 Aug 25. doi:10.3389/fgene.2020.00874
  14. Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in asian Indians. Adipocyte. (2019) Vol 8: 125-136. DOI: 10.1080/21623945.2019.1595269
  15. Systems Genomics of Thigh Adipose Tissue from Asian Indian Type-2 Diabetics Revealed Distinct Protein Interaction Hubs. Front. Genet. (2019) doi.org/10.3389/fgene.2018.00679.
  16. Weighted Gene Co-expression Network Analysis Revealed Pathology of Femoral Subcutaneous Adipose Tissue Implicated in Asian Indian Type-2 Diabetes Mellitus. Scientific Reports (Submitted)
  17. Congenital Pouch Colon: Role of Genetics or Environmental Influence?  Pathobiology (2018) Vol 85(5-6):332-341. DOI: 10.1159/000492432
  18. Draft Genome Sequence of the Plant Growth-Promoting Rhizobacterium Pseudomonas protegens Strain BNJ-SS-45, Isolated from Rhizosphere Soil of Wheat (Triticum aestivum) Microbiol Resour Announc. (2018) 7:e00926-18; doi:10.1128/MRA.00926-18
  19. Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome? Biomolecules. (2018) 6;8(3).
  20. Draft Genome Sequence of a Fungus (Fusarium tricinctum) Cultured from a Monoisolate Native to the Himalayas. Genome Announc (2018) 6:e00365-18. https://doi.org/10.1128/genomeA.00365-18.
  21. Whole exome sequencing reveals rare variants linked to congenital pouch colon. Scientific Reports. (2018) 8:6646 DOI:10.1038/s41598-018-24967-y
  22. A Bioinformatics Pipeline for Whole Exome Sequencing: Overview of the Processing and Steps from Raw Data to Downstream Analysis. bioRxiv preprint (2018). DOI 10.1101/201145
  23. Application of Chromosomal Microarray for Evaluation of Idiopathic Short Stature in Asian Indian Children: A Pilot Study (2018) DOI10.4103/ijem.IJEM_202_17
  24. Dielectric Barrier Discharge based Mercury-free plasma UV-lamp for efficient water disinfection. (2017) Scientific Reports 7(1) DOI 10.1038/s41598-017-17455-2
  25. Histopathological and Immunohistochemical Findings in Congenital Pouch Colon: A Prospective Study. (2017) Pathobiology,  DOI: 10.1159/000460821
  26. Biobleaching of Paper Mulberry (Broussentia papyrifera) Pulp Using Laccase Mediator System. (2016) International Journal of Advanced Biotechnology and Research Vol -7, Issue-4, 2016, pp2067-2077
  27. Quality Assessment of Supplied Drinking Water in Jaipur City, India using PCR based Approach. (2016) Environmental Earth Sciences 75:153
  28. Prevalence of E. coli O157:H7 in water sources: an overview on associated diseases, outbreaks and detection methods. (2015) Diagnostic Microbiol. and Infect. Dis., 82:249 – 264.
  29. Effect of metal ions and chemical compounds on chitinase produced by a newly isolated thermotolerant Paenibacillus sp. BISR-047 and its shelf life. (2015) International Journal of Current Microbiology and Applied Science, 4 (5): 882-891.
  30. Detection of Mutations in TERT, the Genes for Telomerase Reverse Transcriptase, in Indian Patients of Aplastic Anaemia : A Pilot Study. (2014) Journal of the \Aassociation of Physicians of India.  vol 62: 13-17.
  31. Effect of nitrogen sources and C: N ratio on production of manganese peroxidase using Phanerochaete chrysosporium NCIM 1197. (2014) Journal of Pure and Applied Microbiology, 8:1, 481 – 487.
  32. Production and purification of a hyperthermostable chitinase from Brevibacillus formosus BISR-1 isolated from the Great Indian Desert soils. (2014) Extremophiles, 18: 451– 462.
  33. Statistical optimization of medium components to increase the manganese peroxidase productivity by Phanerochaete chrysosporium NCIM 1197. (2013) Biotechnology and Bioprocess Engineering, 18(6): 1176 – 1184.
  34. Cloning and heterologous expression of cellulose free thermostable xylanase from Bacillus brevis. (2014) SpringerPlus 2014, 3:20  doi:10.1186/2193-1801-3-20
  35. Chitinase production by a newly isolated thermotolerant Paenibacillus sp. BISR-047. (2013) Ann Microbiol, DOI 10.1007/s13213-013-0715-9
  36. Arsenic Resistant Microbacterium sp. and evolution of arsenic resistance in bacteria isolated from soil receiving textile discharge. (2013) In: Microbial, Plant and Animal Research. R. Gaur, K. Sharma, and R Chundawat Ed. Nova Science Publishers. pp 9-15.
  37. Role of Microbes in Bioremediation. (2013) Pointer Publishers.  pp 232-248
  38. Analysis of structurally conserved atomic interactions in structural homologues of nicotinamide adenine dinucleotide binding dehydrogenases. (2012). J Computational Biol. Bioinfo. Res. Volume 4(1): 1 – 7.
  39. From Isolation of Potential Microalgal Strains to Strain Engineering for Biofuel. In: Gordon, R. & J. Seckbach, Ed. (2012). The Science of Algal Fuels: Phycology, Geology, Biophotonics, Genomics and Nanotechnology. Dordrecht, Springer. Pp 63 – 81.
  40. Isolation and Characterization of Dunaliella Species from Sambhar Lake (India) and its Phylogenetic Position in the Genus Dunaliella Using 18S rDNA (2012)Nat. Acad. Sci. Lett.  Volume 35(3), 207-213.
  41. Polyphasic characterization of cyanobacteria isolated from desert crusts, and the description of Desertifilum tharense gen. et sp. nov. (Oscillatoriales). (2012) Phycologia Volume 51 (3): 260–270.
  42. Arsenic resistant Microbacterium species and Evolution of arsenic resistance in bacteria isolated from Soil receiving textile discharge. (2012). In: Microbial, Plant and Animal Research. Nova Science Publishers, USA. pp 9-16.
  43. Biotransformation of Nitriles. (2012). In: ‘Recent Advances in Microbiology, Eds., Tiwari S. P. and Sharma R., Singh R. K. pp 461-478
  44. Screening and Characterisation of Pseudomonas fluorescence: A Biological Control Agent against Wilt Fungus in Cajanus cajan (L.) Millsp. (2012) International Journal of Life Sciences. Vol. 1(3) : 175-185.
  45. Phylogenetic inference: gene or proteins? In: Modern trends in Microbial Biodiversity of Natural ecosystems. Sinha, A., Sharma, B.K., Srivastava, M. (Eds). Biotech Books, New Delhi, (2011). pp 289 – 300.
  46. The Diversity Analysis of the Microbial Community in Wastewater by Amplified rDNA Restriction Analysis (ARDRA). (2010) Journal of Ecobiotechnology, 2:4, 51-55.
  47. Synthesis of low cost adhesives from pulp and paper industry waste. (2010) J. Sci. Ind. Res., 69: 390-395.
  48. Nitrilase-catalysed conversion of acrylonitrile by free and immobilized cells of Streptomyces sp. (2009) J. Biosciences, 34 (1): 21-26.
  49. Screening of nitrogen fixers from rhizospheric bacterial isolates associated with important desert plants. (2008) Appl. Ecol. Environ. Res., 6 (2): 101-109.
  50. Evaluation of Plant growth promontory activities of Rhizobacterial isolates from two plants of Thar arid regions. (2008). Asian J. Exp. Sci. 22(3): 205-212.
  51. Screening and characterization of antifungal clusterbean (Cyamopsis tetragonoloba) rhizobacteria, (2008). Biocontrol Science and Technology, 18(2):  139-156.
  52. Optimization of nitrilase production from a new thermophilic isolate. (2007) J. Chem Technol. Biotechnol., 82, 646-651.
  53. Mutagenicity evaluation of industrial sludge from common effluent treatment plant. (2007). Chemosphere 67: 1229-1235.
  54. Biobleaching of non-woody pulps using xylanase of Bacillus brevis BISR-062. (2006). Appl. Biochem. Biotechnol. 128(2): 159-169.
  55. Extraction of bulk DNA from Thar Desert soils for optimization of PCR-DGGE based microbial community analysis. (2007). Elec. J. Biotechnol., (online) DOI: 0.2225/vol 10-issue3-fulltext-6.
  56. The Rheological properties of biological gums. (2006) Proc. Natl. Acad. Sci. India, 76 (B) I: 55-62.
  57. Characterization of extracellular alkaline proteases produced by halophilic bacteria. (2006) Proc. Natl. Acad. Sci. India, 76 (B) IV: 362-367.
  58. Phosphate solubilization by rhizospheric bacterial isolates from economically important desert plants. (2006) Indian J. Microbial. 46 (4): 355-361.
  59. Small scale DNA extraction from soils of hot arid zones. (2006) http://www.protocol-online.org.
  60. Plastic waste recycling trade in Delhi (1999). Warmer Bulletin 65: 14-15
  61. Solid waste management in India: options and opportunities (1998). Resource conservation and recycling 24: 137-154.
  62. Solid Wastes. In: Green India 2047 : a project that looks back to think ahead. (1998) Tata Energy Research Institute, New Delhi.
  63. Biomethanation. (1995) In: Wealth from Wastes. Tata Energy Research Institute, New Delhi.
  64. Metabolism of Ferulic acid by Alcaligenes paradoxes. (1994) Ind. J Microbiol. 34: 303-306.
  65. Degradation of veratraldehyde by Alcaligenes paradoxus. (1993) FEMS Microbiol. Lett. 108: 361-366.
  66. Purification and characterization of endoglucanases of Cellulomonas fimi. (1990) Indi. J Microbiol. 30: 279-285.
  Member of Professional Bodies
 
  • Founder Member, Metabolism and Molecular Research Society, India
  • Life Member, Association of Microbiologists of India
  • Life Member, Mycological Society of India
  • Member, American Association for Advancement of Science, USA
  • Member, American Society for Microbiology, USA
  Current Sponsored Projects
 

Design Innovation Center at Center for Convergence Technologies, UOR, Jaipur (Collaborative project involving four institutions as spokes)

The proposed project aims towards establishment of a platform for increased participation, interaction and mutual co-operation between academia and industry for design innovation. The focus of the proposal is converging technologies. The project aspires to develop a continuously evolving curriculum for innovation in process, product and system design aligned to meet the needs of the industries in the milieu and society at large. We have presentlyidentifiedfive major thrust areas for DIC in accordance with the industrial requirements in the surrounding region and the existing strengths and assets of the centre. Sponsoring Agency: MHRD, Gov of India (1.0 Crore)

 

A Cross-sectional Study on throat microbiome in subjects with sub-clinical rheumatic heart disease or clinical rhumatic heart disease and comparing with normal healthy subjects.

The work involves the comparitive study of microbiome in three sub groups and find the diagnostic components of RHD. Sponsoring Agency RUHS/SP Medical College Bikaner (10.7 lakhs)

  Text and Reference Books
 
  • Wealth from Waste, Published by Tata Energy Research Institute, 1995, New Delhi.
  Intellectual Property Rights (IPR)
 

"A novel dielectric barrier discharge (DBD) based portable  UV/VUV source for water disinfection" reference No. 797DEL2015.

  Member, Editorial Board
 
  • Editor, Indian Journal of Microbiology (1992-95)
  • Member, Expert Review committee, SEED Division, Dept. Science & Technology, Govt of India
  • Member, Biosafety Committee, Birla Institute of Technology & Science, Pilani, Rajasthan.
  • Member, Biosafety Committee, University of Rajasthan, Jaipur. Rajasthan.
  • Ex-Member, State Biotechnology Coordination Committee, Govt. of Rajasthan
  • Ex-Member, BOS, Suresh Gyan Vihar University, Jaipur
  • Member, University Research Board, Thapar University, Patiala
  • Member, BOS, Center for Converging Technologies, UOR, Jaipur
  • Member, Research Advisory committee, Jaipur National University, Jaipur
  • Member, BOS, IIS University, Jaipur
  • Member, BOS, Bioinformatics, M D University, Ajmer