Birla Institute of Technology, Mesra
   
Dr. Venkatesan Jayaprakash
Associate Professor, Pharmaceutical Sciences and Tech
M. Pharm., Ph.D.
Contact Address
Permanent Address 26/46, Ragavendra Street, Komarapalayam, Namakkal-638183 (TN) India
Local Address DI/29, Inner Campus, Birla Institute of Technology, Mesra, Ranchi-835215 (JH) India
Phone (Office) 2275290
Phone Residence 0651-2275555
Email Id venkatesanj@bitmesra.ac.in
Joined Institute on : 16-Feb-2004
  Work Experience
 
Teaching : 15 Years

Research : 15 Years

  Professional Background
  • Associate Professor (Since July 2016), Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi-835215 (JH), India
  • Assistant Professor (Jun 2007 to June 2016), Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215 (JH), India 
  • Lecturer (Feb 2004 to May 2007), Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215 (JH), India 
  • Assisstant Professor (Jul 2002 to Jan 2004), Sanjivani College of Pharmaceutical Sciences, Ketri-333503 (RJ), India 
  • Assistant Professor (Apr 1999 to Jun 2002), JKKMMRF College of Pharmacy, Komarapalayam-638183 (TN), India
  • Tutor (Nov 1996 to Aug 1997), JKKMMRF College of Pharmacy, Komarapalayam-638183 (TN), India
  Research Areas
 

Expertise

  • Organic Synthesis and Medicinal Chemistry
  • Molecular Modeling and Drug Design

Research Area:

  • Antitubercular: Mycobactin bioynthesis inhibitors
  • CNS: Monoamine oxidase inhibitors
  • Anticancer: HDAC inhibitors, RR inhibitors, CDK inhibitors & CYP inhibitors
  • Antivirals: Protease inhibitors (DenV & ChikV) , Fusion inhibitors (DenV)  
  Award and Honours
 
  • 1997-1999, Junior Research Fellowship, University Grants Commission, Government of India
  • 2015, Travel Grant from DBT (DBT/CTEP/02/201501300)- "International Multidisciplinary Symposium on Drug Research and Development" organized by Anadolu University Ataturk Culture & Arts Centre, Eskisehir, Turkey, 15-17 October, 2015 
   Publications
 

Scopus

EXPORT DATE:03 Mar 2019

Scopus Author ID: 23995556000

ORCID ID:Â http://orcid.org/0000-0002-9724-4153

Author h-index: 18

1. Sonawane, V.R., Siddique, M.U.M., Gatchie, L., Williams, I.S., Bharate, S.B., Jayaprakash, V., Sinha, B.N., Chaudhuri, B.CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance (2019) European Journal of Pharmaceutical Sciences, 131, pp. 177-194.

2. Sonawane, V., Mohd Siddique, M.U., Jadav, S.S., Sinha, B.N., Jayaprakash, V., Chaudhuri, B. Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy (2019) European Journal of Medicinal Chemistry, pp. 115-132.

3. Mohd Siddique, M.U., Barbhuiya, T.K., Sinha, B.N., Jayaprakash, V. Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1(2019) European Journal of Medicinal Chemistry, pp. 28-36.

4. Molla, A., Ranjan, S., Rao, M.S., Dar, A.H., Shyam, M., Jayaprakash, V., Hussain, S. Borax Catalysed Domino Synthesis of Highly Functionalised Spirooxindole and Chromenopyridine Derivatives: X-Ray Structure, Hirshfeld Surface Analysis and Molecular Docking Studies (2018) ChemistrySelect, 3 (30), pp. 8669-8677.

5. Bagchi, S., Rathee, P., Jayaprakash, V., Banerjee, S. Farnesyl transferase inhibitors as potential anticancer agents (2018) Mini-Reviews in Medicinal Chemistry, 18 (19), pp. 1611-1623.

6. Siddique, M.U.M., Sinha, B.N., Jayaprakash, V. Comparative shape and electrostatic study of highly potent and selective CYP1B1 inhibitor: Assessment of active site of CYP1B1 by binding mode analysis using site map tool (2018) Indian Journal of Pharmaceutical Education and Research, 52 (1), pp. 159-165.

7. Choudhury, M., Viswanathan, V., Timiri, A.K., Sinha, B.N., Jayaprakash, V., Velmurugan, D. Crystal structures and Hirshfeld surface analyses of 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]- N -(pyridin-2-yl)acetamide and 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]- N -(pyrazin-2-yl)acetamide (2018) Acta Crystallographica Section E: Crystallographic Communications, 74, pp. 718-723.

8. Nath, C., Badavath, V.N., Thakur, A., Ucar, G., Acevedo, O., Mohd Siddique, M.U., Jayaprakash, V. Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A (2018) MedChemComm, 9 (7), pp. 1164-1171.

9. Jadav, S.S., Sinha, B.N., Hilgenfeld, R., Jayaprakash, V. Computer-aided structure based drug design approaches for the discovery of new anti-CHIKV agents (2017) Current Computer-Aided Drug Design, 13 (4), pp. 346-361.

10. Yasmin, S., Capone, F., Laghezza, A., Piaz, F.D., Loiodice, F., Vijayan, V., Devadasan, V., Mondal, S.K., Atll, Ö., Baysal, M., Pattnaik, A.K., Jayaprakash, V., Lavecchia, A. Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes (2017) Scientific Reports, 7 (1), art. no. 14453, . Cited 2 times.

11. Graser-Loescher, G., Schoenhuber, A., Ciglenec, C., Eberl, S., Krupitza, G., Mader, R.M., Jadav, S.S., Jayaprakash, V., Fritzer-Szekeres, M., Szekeres, T., Saiko, P. Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth: Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine (2017) Food and Chemical Toxicology, 108, pp. 53-62. Cited 2 times.

12. Yasmin, S., Jayaprakash, V. Thiazolidinediones and PPAR orchestra as antidiabetic agents: From past to present (2017) European Journal of Medicinal Chemistry, 126, pp. 879-893. Cited 17 times.

13. Subasri, S., Kumar, T.A., Sinha, B.N., Jayaprakash, V., Viswanathan, V., Velmurugan, D. Crystal structures of 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(naphthalen-1-yl)acetamide and 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(4-fluorophenyl)acetamide (2017) Acta Crystallographica Section E: Crystallographic Communications, 73, pp. 306-309. Cited 1 time.

14. Badavath, V.N., Nath, C., Ganta, N.M., Ucar, G., Sinha, B.N., Jayaprakash, V. Design, synthesis and MAO inhibitory activity of 2-(arylmethylidene)-2,3-dihydro-1-benzofuran-3-one derivatives (2017) Chinese Chemical Letters, 28 (7), pp. 1528-1532. Cited 4 times.

15. Subasri, S., Kumar, T.A., Sinha, B.N., Jayaprakash, V., Viswanathan, V., Velmurugan, D. Crystal structures of N-(4-chlorophenyl)-2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]acetamide and N-(3-chlorophenyl)-2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]acetamide (2017) Acta Crystallographica Section E: Crystallographic Communications, 73, pp. 467-471. Cited 1 time.

16. Choudhury, M., Viswanathan, V., Timiri, A.K., Sinha, B.N., Jayaprakash, V., Velmurugan, D. Crystal structures of 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(2,4-dimethylphenyl)acetamide and 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(3-methoxyphenyl)acetamide Choudhury Manisha (2017) Acta Crystallographica Section E: Crystallographic Communications, 73, pp. 996-1000. Cited 2 times.

17. Mohd Siddique, M.U., McCann, G.J.P., Sonawane, V.R., Horley, N., Gatchie, L., Joshi, P., Bharate, S.B., Jayaprakash, V., Sinha, B.N., Chaudhuri, B. Quinazoline derivatives as selective CYP1B1 inhibitors (2017) European Journal of Medicinal Chemistry, 130, pp. 320-327. Cited 17 times.

18. Kasthuri, J.K., Singh Jadav, S., Thripuram, V.D., Gundabolu, U.R., Ala, V.B., Kolla, J.N., Jayaprakash, V., Ahsan, M.J., Bollikolla, H.B. Synthesis, Characterization, Docking and Study of Inhibitory Action of Some Novel C-Alkylated Chalcones on 5-LOX Enzyme (2017) ChemistrySelect, 2 (28), pp. 8771-8778. Cited 2 times.

19. Badavath, V.N., Jadav, S.S., Pastorino, B., De Lamballerie, X., Sinha, B.N., Jayaprakash, V. Synthesis and antiviral activity of 2-aryl-4H-chromen-4-one derivatives against Chikungunya virus (2016) Letters in Drug Design and Discovery, 13 (10), pp. 1019-1024. Cited 2 times.

20. Mule, S.N.R., Nurbhasha, S., Kolla, J.N., Jadav, S.S., Jayaprakash, V., Bhavanam, L.R., Bollikolla, H.B. Synthesis, biological screening and molecular docking studies of novel 4,6-pyrimidine derivatives as EGFR-TK inhibitors (2016) Medicinal Chemistry Research, 25 (11), pp. 2534-2546. Cited 4 times.

21. Mathew, B., Haridas, A., Uçar, G., Baysal, I., Adeniyi, A.A., Soliman, M.E.S., Joy, M., Mathew, G.E., Lakshmanan, B., Jayaprakash, V. Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors (2016) International Journal of Biological Macromolecules, 91, pp. 680-695. Cited 25 times.

22. Thakur, A., Dan, N., Bhakat, S., Jayaprakash, V., Banerjee, S. 5' adenosine monophosphate-activated protein kinase modulators as anticancer agents (2016) Anti-Cancer Agents in Medicinal Chemistry, 16 (8), pp. 961-972. Cited 1 time.

23. Mathew, B., Haridas, A., Suresh, J., Mathew, G.E., Uçar, G., Jayaprakash, V. Monoamine oxidase inhibitory action of chalcones: A Mini Review (2016) Central Nervous System Agents in Medicinal Chemistry, 16 (2), pp. 120-136. Cited 21 times.

24. Mathew, B., Mathew, G.E., Uçar, G., Baysal, I., Suresh, J., Mathew, S., Haridas, A., Jayaprakash, V. Potent and Selective Monoamine Oxidase-B Inhibitory Activity: Fluoro- vs. Trifluoromethyl-4-hydroxylated Chalcone Derivatives (2016) Chemistry and Biodiversity, pp. 1046-1052. Cited 11 times.

25. Mathew, B., Mathew, G.E., Suresh, J., Ucar, G., Sasidharan, R., Anbazhagan, S., Vilapurathu, J.K., Jayaprakash, V. Monoamine oxidase inhibitors: Perspective design for the treatment of depression and neurological disorders (2016) Current Enzyme Inhibition, 12 (2), pp. 115-122. Cited 8 times.

26. Timiri, A.K., Sinha, B.N., Jayaprakash, V. Progress and prospects on DENV protease inhibitors (2016) European Journal of Medicinal Chemistry, 117, pp. 125-143. Cited 14 times.

27. Badavath, V.N., Baysal, I., Ucar, G., Sinha, B.N., Jayaprakash, V. Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis (2016) ACS Medicinal Chemistry Letters, 7 (1), pp. 56-61. Cited 21 times.

28. Yasmin, S., Jayaprakash, V. Design, in silico docking and predictive ADME properties of some thiazolidine-2, 4-diones derivatives as PPARγ modulators (2016) International Journal of Pharmacy and Pharmaceutical Sciences, 8 (5), pp. 143-150.

29. Badavath, V.N., Ucar, G., Sinha, B.N., Mondal, S.K., Jayaprakash, V. Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis-II (2016) ChemistrySelect, 1 (18), pp. 5879-5884. Cited 3 times.

30. Badavath, V.N., Baysal, I., Uçar, G., Mondal, S.K., Sinha, B.N., Jayaprakash, V. Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis (2016) Archiv der Pharmazie, 349 (1), pp. 9-19. Cited 10 times.

31. Subasri, S., Timiri, A.K., Barji, N.S., Jayaprakash, V., Vijayan, V., Velmurugan, D. Crystal structures of 2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]-N-(3-nitrophenyl)acetamide monohydrate and N-(2-chlorophenyl)-2-[(4,6-diaminopyrimidin-2-yl)sulfanyl]acetamide (2016) Acta Crystallographica Section E: Crystallographic Communications, 72, pp. 1171-1175. Cited 3 times.

32. Mohd Siddique, M.U., McCann, G.J.P., Sonawane, V., Horley, N., Williams, I.S., Joshi, P., Bharate, S.B., Jayaprakash, V., Sinha, B.N., Chaudhuri, B. Biphenyl urea derivatives as selective CYP1B1 inhibitors (2016) Organic and Biomolecular Chemistry, 14 (38), pp. 8931-8936. Cited 14 times.

33. Mathew, B., Haridas, A., Uçar, G., Baysal, I., Joy, M., Mathew, G.E., Lakshmanan, B., Jayaprakash, V. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors (2016) ChemMedChem, pp. 1161-1171. Cited 18 times.

34. Hatti, I., Sreenivasulu, R., Jadav, S.S., Jayaprakash, V., Kumar, C.G., Raju, R.R. Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives (2015) Medicinal Chemistry Research, 24 (8), pp. 3305-3313. Cited 19 times.

35. Timiri, A.K., Subasri, S., Kesherwani, M., Vishwanathan, V., Sinha, B.N., Velmurugan, D., Jayaprakash, V. Synthesis and molecular modelling studies of novel sulphonamide derivatives as dengue virus 2 protease inhibitors (2015) Bioorganic Chemistry, 62, art. no. 1832, pp. 74-82. Cited 11 times.

36. Jadav, S.S., Kaptein, S., Timiri, A., De Burghgraeve, T., Badavath, V.N., Ganesan, R., Sinha, B.N., Neyts, J., Leyssen, P., Jayaprakash, V. Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus e protein inhibitors (2015) Bioorganic and Medicinal Chemistry Letters, 25 (8), pp. 1747-1752. Cited 12 times.

37. Badavath, V.N., Sinha, B.N., Jayaprakash, V. Design, in-silico docking and predictive adme properties of novel pyrazoline derivatives with selective human MAO inhibitory activity (2015) International Journal of Pharmacy and Pharmaceutical Sciences, 7 (12), pp. 277-282. Cited 3 times.

38. Jadav, S.S., Kumar, A., Ahsan, M.J., Jayaprakash, V. Ebola virus: Current and future perspectives (2015) Infectious Disorders - Drug Targets, 15 (1), pp. 20-31. Cited 3 times.

39. Jadav, S.S., Sinha, B.N., Pastorino, B., De Lamballerie, X., Hilgenfeld, R., Jayaprakash, V. Identification of pyrazole derivative as an antiviral agent against chikungunya through HTVS (2015) Letters in Drug Design and Discovery, 12 (4), pp. 292-301. Cited 8 times.

40. Bhakat, S., Delang, L., Kaptein, S., Neyts, J., Leyssen, P., Jayaprakash, V. Reaching beyond HIV/HCV: Nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus (2015) RSC Advances, 5 (104), pp. 85938-85949. Cited 5 times.

41. Alavala, R.R., Kulandaivelu, U., Bonagiri, P., Boyapati, S., Jayaprakash, V., Subramaniam, A.T. Synthesis and antiviral activity of dihydropyrimidines – ciprofloxacin mannich bases against various viral strains (2015) Anti-Infective Agents, 13 (2), pp. 154-165. Cited 1 time.

42. Nayak, B.V., Ciftci-Yabanoglu, S., Bhakat, S., Timiri, A.K., Sinha, B.N., Ucar, G., Soliman, M.E.S., Jayaprakash, V. Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones (2015) Bioorganic Chemistry, 58, pp. 72-80. Cited 19 times.

43. Bhakat, S., Karubiu, W., Jayaprakash, V., Soliman, M.E.S. A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses (2014) European Journal of Medicinal Chemistry, 87, pp. 677-702. Cited 22 times.

44. Rathinavelusamy, P., Mazumder, P.M., Sasmal, D., Jayaprakash, V. Evaluation of in silico, in vitro α-amylase inhibition potential and antidiabetic activity of Pterospermum acerifolium bark (2014) Pharmaceutical Biology, 52 (2), pp. 199-207. Cited 3 times.

45. Bojanapu, A., Subramaniam, A.T., Munusamy, J., Dhanapal, K., Chennakesavalu, J., Sellappan, M., Jayaprakash, V. Validation and method development of tadalafil in bulk and tablet dosage form by RP-HPLC (2014) Drug Research, 65 (2), pp. 82-85. Cited 3 times.

46. Paramaguru, R., Mazumder, P.M., Sasmal, D., Jayaprakash, V. Antidiabetic activity of pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in l6 muscle cell lines with its HPLC fingerprint (2014) BioMed Research International, 2014, art. no. 459376, . Cited 4 times.

47. Subasri, S., Kumar, T.A., Sinha, B.N., Jayaprakash, V., Velmurugan, D. 2-[(4,6-Diaminopyrimidin-2-yl)sulfanyl]-N-(2-methylphenyl)acetamide (2014) Acta Crystallographica Section E: Structure Reports Online, 70 (8), pp. o850. Cited 4 times.

48. Jadav, S.S., Sinha, B.N., Hilgenfeld, R., Pastorino, B., De Lamballerie, X., Jayaprakash, V. Thiazolidone derivatives as inhibitors of chikungunya virus (2014) European Journal of Medicinal Chemistry, 89, pp. 172-178. Cited 22 times.

49. Kulandaivelu, U., Chilakamari, L.M., Jadav, S.S., Rao, T.R., Jayaveera, K.N., Shireesha, B., Hauser, A.-T., Senger, J., Marek, M., Romier, C., Jung, M., Jayaprakash, V. Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8 (2014) Bioorganic Chemistry, 57, pp. 116-120. Cited 5 times.

50. Vishnu Nayak, B., Ciftci-Yabanoglu, S., Jadav, S.S., Jagrat, M., Sinha, B.N., Ucar, G., Jayaprakash, V. Monoamine oxidase inhibitory activity of 3,5-biaryl-4,5-dihydro-1H- pyrazole-1-carboxylate derivatives (2013) European Journal of Medicinal Chemistry, 69, pp. 762-767. Cited 30 times.

51. Kulandaivelu, U., Shireesha, B., Mahesh, C., Vidyasagar, J.V., Rao, T.R., Jayaveera, K.N., Saiko, P., Graser, G., Szekeres, T., Jayaprakash, V. Synthesis antimicrobial and anticancer activity of N′- arylmethylidene-piperazine-1-carbothiohydrazide (2013) Medicinal Chemistry Research, 22 (6), pp. 2802-2808. Cited 6 times.

52. Mahapatra, M., Kulandaivelu, U., Saiko, P., Graser, G., Szekeres, T., Andrei, G., Snoeck, R., Balzarini, J., Jayaprakash, V. Methyl-2-arylidene hydrazinecarbodithioates: Synthesis and biological activity (2013) Chemical Papers, 67 (6), pp. 650-656. Cited 2 times.

53. Ferreras, J.A., Gupta, A., Amin, N.D., Basu, A., Sinha, B.N., Worgall, S., Jayaprakash, V., Quadri, L.E.N. Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis (2011) Bioorganic and Medicinal Chemistry Letters, 21 (21), pp. 6533-6537. Cited 6 times.

54. Jagrat, M., Behera, J., Yabanoglu, S., Ercan, A., Ucar, G., Sinha, B.N., Sankaran, V., Basu, A., Jayaprakash, V. Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies (2011) Bioorganic and Medicinal Chemistry Letters, 21 (14), pp. 4296-4300. Cited 36 times.

55. Kulandaivelu, U., Padmini, V.G., Suneetha, K., Shireesha, B., Vidyasagar, J.V., Rao, T.R., Jayaveera, K.N., Basu, A., Jayaprakash, V. Synthesis, antimicrobial and anticancer activity of new thiosemicarbazone derivatives (2011) Archiv der Pharmazie, 344 (2), pp. 84-90. Cited 20 times.

56. Saiko, P., Graser, G., Giessrigl, B., Lackner, A., Grusch, M., Krupitza, G., Basu, A., Sinha, B.N., Jayaprakash, V., Jaeger, W., Fritzer-Szekeres, M., Szekeres, T. A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C) (2011) Biochemical Pharmacology, 81 (1), pp. 50-59. Cited 11 times.

57. Jayaprakash, V., Yabanoglu, S., Sinha, B.N., Ucar, G. Pyrazoline-based mycobactin analogues as dual inhibitors of MAO/cholinesterase [MAO ve kolinesteraz dual i?nhibitörü pirazolin-bazli mikobaktin analoglari]] (2010) Turkish Journal of Biochemistry, 35 (2), pp. 91-98. Cited 12 times.

58. Chetan, B., Bunha, M., Jagrat, M., Sinha, B.N., Saiko, P., Graser, G., Szekeres, T., Raman, G., Rajendran, P., Moorthy, D., Basu, A., Jayaprakash, V. Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity (2010) Bioorganic and Medicinal Chemistry Letters, 20 (13), pp. 3906-3910. Cited 41 times.

59. Mishra, N., Oraon, A., Dev, A., Jayaprakash, V., Basu, A., Pattnaik, A.K., Tripapthi, S.N., Akhtar, M., Ahmad, S., Swaroop, S., Basu, M. Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation (2010) Journal of Ethnopharmacology, 128 (2), pp. 533-536. Cited 12 times.

60. Chakrabarty, S., Jasmine, Bhadaliya, C., Sinha, B.N., Mahesh, A., Bai, H., Blond, S.Y., Jayaprakash, V. Inhibitors of human histone deacetylase: Synthesis and enzyme assay of hydroxamates with piperazine linker (2010) Archiv der Pharmazie, 343 (3), pp. 167-172. Cited 5 times.

61. Karuppasamy, M., Mahapatra, M., Yabanoglu, S., Ucar, G., Sinha, B.N., Basu, A., Mishra, N., Sharon, A., Kulandaivelu, U., Jayaprakash, V. Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies (2010) Bioorganic and Medicinal Chemistry, 18 (5), pp. 1875-1881. Cited 39 times.

62. Sahoo, A., Yabanoglu, S., Sinha, B.N., Ucar, G., Basu, A., Jayaprakash, V. Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies (2010) Bioorganic and Medicinal Chemistry Letters, 20 (1), pp. 132-136. Cited 55 times.

63. Mishra, N., Basu, A., Jayaprakash, V., Sharon, A., Basu, M., Patnaik, K.K. Structure based virtual screening of GSK-3β: Importance of protein flexibility and induced fit (2009) Bioorganic and Medicinal Chemistry Letters, 19 (19), pp. 5582-5585. Cited 7 times.

64. Basu, A., Jasu, K., Jayaprakash, V., Mishra, N., Ojha, P., Bhattacharya, S. Development of CoMFA and CoMSIA models of cytotoxicity data of anti-HIV-1-phenylamino-1H-imidazole derivatives (2009) European Journal of Medicinal Chemistry, 44 (6), pp. 2400-2407. Cited 33 times.

65. Jayaprakash, V., Sinha, B.N., Ucar, G., Ercan, A. Pyrazoline-based mycobactin analogues as MAO-inhibitors (2008) Bioorganic and Medicinal Chemistry Letters, 18 (24), pp. 6362-6368. Cited 50 times.

66. Dewangan, P., Verma, S.M., Basu, A., Venkatesan, J. Multidimensional consensus QSAR: A step towards integrating CoMFA, CoMSIA with traditional QSAR methodologies (2008) Letters in Drug Design and Discovery, 5 (8), pp. 494-502. Cited 1 time.

67. Krishnan, K., Prathiba, K., Jayaprakash, V., Basu, A., Mishra, N., Zhou, B., Hu, S., Yen, Y. Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones (2008) Bioorganic and Medicinal Chemistry Letters, 18 (23), pp. 6248-6250. Cited 27 times.

68. Stirrett, K.L., Ferreras, J.A., Jayaprakash, V., Sinha, B.N., Ren, T., Quadri, L.E.N. Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis (2008) Bioorganic and Medicinal Chemistry Letters, 18 (8), pp. 2662-2668. Cited 47 times.

69. Venkatesan, J., Pandeya, S., Selvakumar, D. Synthesis and biological evaluation of 4,6-diaryl substituted-4,5-dihydro- 2-amino pyrimidines (2007) Indian Journal of Pharmaceutical Sciences, 69 (4), pp. 586-589. Cited 7 times.

70. Venkatesan, J., Pandeya, S.N., Selvakumar, D., Babuthandapani, A. Synthesis and biological evaluation of 4,6-diaryl substituted- 4,5-dihydro pyrimidinyl-2-ureas (2005) Indian Drugs, 42 (7), pp. 447-452.

  Member of Professional Bodies
 

 

  • Registered Pharmacist (17905 A2), Tamilnadu Pharmacy Council, Vadapalani, Chennai-600026 (TN), India
  • APTI Life Member (TN/LM-187), H.Q: No.620 D, 35th Cross, 2nd Block, Rajajinagar, Bengaluru-560 010 (KA), India
  Current Sponsored Projects
 

Co-Principal Investigator

Title: Design and Synthesis of Substrate Based Peptide Inhibitors of DENV Protease for the Treatment of Dengue Viral Infections

Principal Investigator: Dr. Barij Nayan Sinha & Co-Principal Investigator: Dr. B. Sarkar

Scheme & Agency: EMR (Individual Centric), Science & Engineering Research Board, DST,  Govt. of India, India

File No.: EMR/2016/005711

Amount Sanctioned: 45,60,400/-

Duration: Three years (2017-2020)

Principal Investigator

Title: Phenyloxazoline Synthetase Inhibitors as Antitubercular Agents (POSIAA)

Co-Principal Investigator: Dr. Abhimanyu Dev

Scheme & Agency: EMR (Individual Centric), Science & Engineering Research Board, DST,  Govt. of India, India

File No.: EMR/2016/000675

Amount Sanctioned: 53,73,450/-

Duration: Three years (2016-2019)

Research Group Member & Co-supervisor for the scholar enrolled under the project

Title: Design & Synthesis of potent dual inhibitors of Cdk-4 and tubulin as anticancer agents

Principle Investigator: Prof. B. N. Sinha

Scheme & Agency: An Indo-UK Project sponsored by University Grants Commission (UGC), Govt. of India, India

Amount Sanctioned: 30,88,800/-

Duration: Two years (2013-2015)

Research Group Member & Co-supervisor for the scholar enrolled under the project

Title: Structure-based discovery of antivirals for the treatment of Chikungunya virus infections (Anti-Chick)

Principle Investigator: Prof. B. N. Sinha

Scheme & Agency: New-Indigo Eranet, An Indo-German Project sponsored by Department of Biotechnology (DBT), Ministry of Science & Technology, Govt. of India, India

Amount Sanctioned: 34,62,000/-

Duration: (Two Years) 2011-2013

Research Group Member & Co-supervisor for the scholar enrolled under the project

Title: Structure-based design of Dengue virus protease inhibitors

Principle Investigator: Prof. B. N. Sinha

Scheme & Agency: An Indo-German Project sponsored by Department of Biotechnology (DBT), Ministry of Science & Technology, Govt. of India, India

Amount Sanctioned: 24,51,800/-

Duration: (3 Years) 2011-2014

Co-principle Investigator

Title: Grid-based Virtual Screening for TB (Grid-ViSiT)

Principle Investigator: K. K. Patnaik, Dept. of Comp. Sci. Engg., BIT, Mesra

Scheme & Agency: Research Promotion Scheme (RPS) sponsored by All IndiaCouncil for Technical Education (AICTE), Govt. of India, India

Amount Sanctioned: Rs. 6,50,000/-

Duration: (Two Years) 2008-2010

  Text and Reference Books
 

Book

Venkatesan Jayaprakash, Barij Nayan Sinha, Anti-tubercular Drug Design Exploring Mycobactin Biosynthetic Pathway, Designing molecules that mimics hydroxyphenyl oxazoline portion of mycobactin, LAP Lambert Academic Publication, Germany, 2013 (ISBN:978-3-659-43995-7)

Book Chapter

Venkatesan Jayaprakash, Ajay Kumar Timiri, Barij Nayan Sinha, "Studies on Inhibitors of Dengue Virus Protease", Advances in Studies on Enzyme Inhibitors As Drugs: Anticancer and Antiviral Drugs, Vol. I, Editor, S. P. Gupta, Nova Science Publisher Inc., New York, 2017(ISBN:978-1-53610-504-9)

  Patent
 
  • Application No. 325/KOL/2014 A; Title: 2-(4,6-diaminopyrimidin-2-ylthio)-N-aryl acetamide derivatives, their synthesis, antiviral activity and methods thereof
  • Application No. 191/KOL/2014 A; Title: 4-(1,3-dioxoisoindolin-2-yl)-benzenesulfonamide derivatives, their synthesis, antiviral activity and methods thereof
  • Application No. 811/KOL/2013; Title: Arylmethylidene heterocyclics as novel antiviral agents against chikungunya viral infection
  • Application No. 349/CHE/2011; Title: Dihydropyrimidine Derivatives as pharmacologically active agents
  Member, Editorial Board
 

Editor: Journal of Pharmaceutical Chemistry (ISSN: 2349-5731)

Editorial Board Member: PHARMBIT (ISSN: 0973-6204)