Birla Institute of Technology, Mesra
   
DR. (MRS.) NEELIMA SHARMA
Assistant Professor , Pharmaceutical Sciences and Tech
M.Sc., Ph.D.
Contact Address
Residence Address F. No. 102, Neerav Appartment, Sikandra, Agra, U.P.
Permanent Address D-I/10, Birla Institute of Technology, Mesra-835215, Ranchi
Phone (Office) 06512276247
Phone Residence 09470978418
Email Id nsharma@bitmesra.ac.in
   Joined Institute on : 4-Feb-2009

  Work Experience
 
Teaching : 7 Years

Research : 12 Years


  Professional Background
 

1. Qualify GATE in 2003

2. Qualify NET in 2003

3. Junior  Research Fellow, Indian Institute of Toxicology and Research (IITR), Lucknow. 2004-2006

 4. Senior  Research Fellow, Indian Institute of Toxicology and Research (IITR), Lucknow. 2006-2009

 


  Research Areas
 

1. Animal Cell Culture (in vitro studies)

2. Toxicological and Biocompatibility evaluations of various synthetic and natural moieties.

3. Biochemical studies for evaluation of biological activities of bioactive molecules.

4. Molecular mechanism of bioactive compounds from both synthetic and natural sources.

 


  Award and Honours
 

1. Holder of  Scholarship Award issued by U.P. Board  (1997-1998)

2. Junior  Research Fellowship (2004-2006)

3. Senior  Research Fellowship (2006-2009)

 


   Publications
 

1.      Pathak, N., Khandelwal, S. (2006). Oxidative stress and apoptotic changes in murine splenocytes   exposed to cadmium. Toxicology  220, 26-36.

 

2.      Pathak, N., Khandelwal, S. (2006). Influence of cadmium on murine thymocytes : potentiation of  apoptosis and oxidative stress. Toxicol. Lett. 165, 121-132.

3.      Pathak, N., Khandelwal, S. (2006). Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and  blastogenesis. Biochem. Pharmacol. 72, 486-497.

4. Pathak, N., Khandelwal, S. (2007). Role of oxidative stress and apoptosis in cadmium induced  thymic atrophy and splenomegaly in mice. Toxicol. Lett. 169, 95-108.

5. Pathak, N., Khandelwal, S. (2007).  Cytoprotective  and  immunomodulating properties  of  Piperine on murine   splenocytes  : an  in vitro  study  - Eur. J.  Pharmacol. 576, 160-170.

6.      NeelimaPathak (Sharma), ShashiKhandelwal (2008). Impact of  cadmium  in T lymphocyte subsets and cytokine expression: Differential regulation by oxidative stress and apoptosis. Biometals 21,179-187.

7.      NeelimaPathak (Sharma), ShashiKhandelwal (2008). Immunomodulation by piperine, curcumin and picroliv in Cd induced murine lymphocytes. Biometals 21, 649-661.

8.  ShashiKhandelwal, NeelimaPathak (Sharma), Manish Kumar Singh (2008). Protective role of piperine against Cadmium induced hepatic and renal toxicity in mice. Toxicol. Int.15, 85-89.

9. NeelimaPathak (Sharma), ShashiKhandelwal (2009). Immunomodulatory  role of  Piperine  in Cadmium induced thymic atrophy and splenomegaly in mice. Environ. Toxicol. Pharmacol. 28,  52-60

10.  NeelimaPathak (Sharma), ShashiKhandelwal (2009). Phenotypic alterations and cytokine ex-pression by cadmium in murine lymphocytes: an in vitro and in vivo study.Toxicol. Int.16, 111-115.

11.  Rishi Sharma, Alok Kr. Pandey ,Neelima Sharma, D. Sasmal, P.K. Barhai (2010). Diamond like carbon films as a protective surface on PMMAfor biomedical applications. Surface & Coatings Technology 205, 2495–2502.

12.  NeelimaPathak (Sharma),SumontoMitra,ShashiKhandelwal (2013). Cadmium Induces Thymocyte Apoptosis via Caspase-Dependent and Caspase-Independent Pathways. J. Biochem. Mol. Toxicol. 27, 193–203.

13.  Anoop Kumar, D. Sasmal, Neelima Sharma (2013). Deltamethrin induced apoptogenic signalling pathway in murine thymocytes : Exploring the molecular mechanism. J Appl. Toxicol. 34:1303-1310.

14.  Neelima Sharma and Anoop Kumar (2013).Tributyltin induced apoptosis on murine thymocytes: Exploring the molecular mechanism. Cell Biol. Toxicol. 30, 101-112.

15.  Anoop Kumar, Neelima Sharma, Sneha Singh, D. Sasmal and Abhimanyu Dev. (2014). Oral vaccine antigen induced immune response signalling pathways: current and future Perspectives. J. Vaccine and Vaccination. 5, 2-6.

16.  Anoop Kumar, D. Sasmal, Neelima Sharma (2014).Understanding of Complex Signaling Pathways of Immune System: A Review. World J. Pharmacy and Pharmaceutical Sci. 3:241-255.

17.  Anoop Kumar, D.Sasmal, Amand Bhaskar, Kunal Mukhopadhyay, Aman Thakurand Neelima Sharma (2014). Deltamethrin induced oxidative stress and mitochondrial caspase dependent signaling pathways in murine splenocytes. Envoiremental Toxicology. DOI No. 10.1002/tox.22091.

18.  S. Mahanti, Rishi Sharma, Ashwini Kr. Singh, Neelima Sharma, S. K. Pradhan, and P. K. Barhai (2014). Correlation of Mechanical Properties with Surface Morphology of Diamond-Like Carbon Films Deposited By Plasma Enhanced Chemical Vapour Deposition Technique. International Journal of Innovative Research in Science, Engineering and Technology. 3: 15510-15517

20.  Anoop Kumar, D.Sasmal, Neelima Sharma (2015). Immunomodulatory role of piperine in Deltamethrin induced thymic apoptosis and altered immune functions.Envoiremental Toxicology and Pharmacology. DOI:  10.1016/j.etap.2014.12.021.

21.  Anoop Kumar, D.Sasmal and Neelima Sharma (2015). An insight into Deltamethrin induced apoptotic calcium, p53 and oxidative stress signalling pathways. Toxicology and Envoiremental Health Sciences. Accepted .

22.  Anoop Kumar, D.Sasmal, Amand Bhaskar, Kunal Mukhopadhyay and Neelima Sharma 2015. Mechanism of Deltamethrin induced immunotoxicity: Current and Future Perceptive.  Receptor and clinical investigation. DOI: 10.14800/rci.578

23.  Anoop kumar, D.Sasmal and Neelima sharma (2015). Comparative efficacy of piperine and curcumin in Deltamethrin induced splenic apoptosis and altered immune functions. Biochemical Pharmacology. Pesticide Biochemistry and Physiology.                                                  DOI:  10.1016/j.pestbp.2015.03.003

24.  Kumar A, sasmal D and sharma N. (2015) Mechanism of immunoprotective effects of curcumin in dlm-induced thymic apoptosis and altered immune functions: an in silico and in vitro study. Journal of Immuntoxicology and Immunopharmacology. Accepted manuscript. Impact factor: 1.14.

25.  Kumar A, dubey R.K, kant K, sasmal D, ghosh M, sharma N. (2015) Determination of deltamethrin concentration in mice plasma and primary immune organs by simple reverse phase hplc. acta chromatographia. doi: 10.1556/1326.2016.28.2.4. Impact factor: 0.577.

26.  Divakar D, sasmal D, Kumar A, and sharma N. (2015) Prophylactic role of piprine and curcumin in allethrin altered hematological and biochemical parameters in Swiss albino mice. Pharmacologia. 6: 396-412.

27.  Kumar A, Sharma N and Sasmal D. (2015). Understanding of statistics in testing of pharmacological hypothesis. Pharmawave. 8:64-72.

28.  Kumar A*, Sasmal D, Sharma N, Bhaskar A, Chandra S, Mukhopadhyay K, Kumar M. (2015) Deltamethrin, a pyrethroid insecticide, could be a promising candidate as an anticancer agent. Medical Hypotheses. 85: 145-147. Impact factor: 1.14.

29.  R. Sharma, N. Sharma, R. Parmar, V. Chatterjee, A. Kumar. Nanocrystalline diamond films as a protective coating for implantable bio-devices. Adv. Mater. Lett. 201 6, 7(8), 100-150
 

 


  Member of Professional Bodies
 

1. Life member of Society of Toxicology India (STOX, India).

2. Jt. Treasurer of  Pharmaceutical Society, Birla Institute of Technology, Mesra, Ranchi.


  Current Sponsored Projects
 

1. Evaluation of Apoptotic Mechanism of  Deltamethrin as a promising candidate against cancer , funded by BIT, Mesrea, Seed Money Scheme, (Principal Investigator) sanctioned amount Rs. 80,000, duration Nov 2015 – 2016. (1 years)

2.Studies  on  Immunotoxic Profile and Proteomics of Deltamethrin in Murine Thymocytes and Splenocytes: Attenuation by Herbals , Funded by UGC, Major Research Project Scheme, (Principal Investigator) sanctioned amount Rs. 9.30 lakhs, duration Feb 2011 – 2014. (3 years)




  Fellow
 

PhD Scholar (Awarded)

1. Anoop Kumar


  Member, Editorial Board
 

1.    Member of the Reviewer Board of Biological Trace Element Research.

        2. Member of the Advisory Board of PHARMBIT.