Birla Institute of Technology, Mesra
Dr. (Mrs.) Neelima Sharma
Assistant Professor, Pharmaceutical Sciences and Tech
Ph.D.
Contact Address
Permanent Address D-I/10, Birla Institute of Technology, Mesra-835215, Ranchi
Local Address Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra-835215, Ranchi
Phone (Office) 06512276247
Phone Residence 09470978418
Email Id nsharma@bitmesra.ac.in
Joined Institute on : 5-Feb-2009

  Work Experience
 
Teaching : 14 Years

Research : 14 Years

  Professional Background

1. Qualify GATE in 2003

2. Qualify NET in 2003

3. Junior  Research Fellow, Indian Institute of Toxicology and Research (IITR), Lucknow. 2004-2006

 4. Senior  Research Fellow, Indian Institute of Toxicology and Research (IITR), Lucknow. 2006-2009

 

  Research Areas
 

1. Animal Cell Culture (in vitro studies)

2. Toxicological and Biocompatibility evaluations of various synthetic and natural moieties.

3. Biochemical studies for evaluation of biological activities of bioactive molecules.

4. Molecular mechanism of bioactive compounds from both synthetic and natural sources.

 

  Award and Honours
 

1. Holder of  Scholarship Award issued by U.P. Board  (1997-1998)

2. Junior  Research Fellowship (2004-2006)

3. Senior  Research Fellowship (2006-2009)

 

  Publications
 

  1. Pathak, N., Khandelwal, S. (2006). Oxidative stress and apoptotic changes in murine splenocytes   exposed to cadmium. Toxicology  220, 26-36.
  2. Pathak, N., Khandelwal, S. (2006). Influence of cadmium on murine thymocytes : potentiation of  apoptosis and oxidative stress. Toxicol. Lett. 165, 121-132.
  3. Pathak, N., Khandelwal, S. (2006). Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and  blastogenesis. Biochem. Pharmacol. 72, 486-497.
  4. Pathak, N., Khandelwal, S. (2007). Role of oxidative stress and apoptosis in cadmium induced  thymic atrophy and splenomegaly in mice. Toxicol. Lett. 169, 95-108.
  5. Pathak, N., Khandelwal, S. (2007).  Cytoprotective  and  immunomodulating properties  of  Piperine on murine   splenocytes  : an  in vitro  study  - Eur. J.  Pharmacol. 576, 160-170.
  6. Neelima Pathak (Sharma), Shashi Khandelwal (2008). Impact of  cadmium  in T lymphocyte subsets and cytokine expression: Differential regulation by oxidative stress and apoptosis. Biometals 21,179-187.
  7. Neelima Pathak (Sharma), Shashi Khandelwal (2008). Immunomodulation by piperine, curcumin and picroliv in Cd induced murine lymphocytes. Biometals 21, 649-661.
  8. ShashiKhandelwal, NeelimaPathak (Sharma), Manish Kumar Singh (2008). Protective role of piperine against Cadmium induced hepatic and renal toxicity in mice. Toxicol. Int.15, 85-89.
  9. Neelima Pathak (Sharma), Shashi Khandelwal (2009). Immunomodulatory  role of  Piperine  in Cadmium induced thymic atrophy and splenomegaly in mice. Environ. Toxicol. Pharmacol. 28,  52-60
  10. Neelima Pathak (Sharma), Shashi Khandelwal (2009). Phenotypic alterations and cytokine ex-pression by cadmium in murine lymphocytes: an in vitro and in vivo study.Toxicol. Int.16, 111-115.
  11. Rishi Sharma, Alok Kr. Pandey, Neelima Sharma, D. Sasmal, P.K. Barhai (2010). Diamond like carbon films as a protective surface on PMMAfor biomedical applications. Surface & Coatings Technology 205, 2495–2502.
  12. Neelima Pathak (Sharma),SumontoMitra,ShashiKhandelwal (2013). Cadmium Induces Thymocyte Apoptosis via Caspase-Dependent and Caspase-Independent Pathways. J. Biochem. Mol. Toxicol. 27, 193–203.
  13. Anoop Kumar, D. Sasmal, Neelima Sharma (2013). Deltamethrin induced apoptogenic signalling pathway in murine thymocytes : Exploring the molecular mechanism. J Appl. Toxicol. 34:1303-1310.
  14. Neelima Sharma and Anoop Kumar (2013).Tributyltin induced apoptosis on murine thymocytes: Exploring the molecular mechanism. Cell Biol. Toxicol. 30, 101-112.
  15. Anoop Kumar, Neelima Sharma, Sneha Singh, D. Sasmal and Abhimanyu Dev. (2014). Oral vaccine antigen induced immune response signalling pathways: current and future Perspectives. J. Vaccine and Vaccination. 5, 2-6.
  16. Anoop Kumar, D. Sasmal, Neelima Sharma (2014).Understanding of Complex Signaling Pathways of Immune System: A Review. World J. Pharmacy and Pharmaceutical Sci. 3:241-255.
  17. Anoop Kumar, D.Sasmal, Amand Bhaskar, Kunal Mukhopadhyay, Aman Thakur and Neelima Sharma (2014). Deltamethrin induced oxidative stress and mitochondrial caspase dependent signaling pathways in murine splenocytes. Envoiremental Toxicology. DOI No. 10.1002/tox.22091.
  18. S. Mahanti, Rishi Sharma, Ashwini Kr. Singh, Neelima Sharma, S. K. Pradhan, and P. K. Barhai (2014). Correlation of Mechanical Properties with Surface Morphology of Diamond-Like Carbon Films Deposited By Plasma Enhanced Chemical Vapour Deposition Technique. International Journal of Innovative Research in Science, Engineering and Technology. 3: 15510-15517
  19. Anoop Kumar, D.Sasmal, Neelima Sharma (2015). Immunomodulatory role of piperine in Deltamethrin induced thymic apoptosis and altered immune functions. Envoiremental Toxicology and Pharmacology. 39, 504-514.
  20. Anoop Kumar, D.Sasmal and Neelima Sharma (2015). An insight into Deltamethrin induced apoptotic calcium, p53 and oxidative stress signalling pathways. Toxicology and Envoiremental Health Sciences. 7,25-34 .
  21. Anoop Kumar, D.Sasmal, Amand Bhaskar, Kunal Mukhopadhyay and Neelima Sharma 2015. Mechanism of Deltamethrin induced immunotoxicity: Current and Future Perceptive.  Receptor and clinical investigation. DOI: 10.14800/rci.578
  22. Anoop kumar, D.Sasmal and Neelima sharma (2015). Comparative efficacy of piperine and curcumin in Deltamethrin induced splenic apoptosis and altered immune functions. Biochemical Pharmacology. Pesticide Biochemistry and Physiology. 119,16-27.
  23. Kumar A, Sasmal D, Sharma N, Bhaskar A, Chandra S, Mukhopadhyay K, Kumar M. (2015) Deltamethrin, a pyrethroid insecticide, could be a promising candidate as an anticancer agent. Medical Hypotheses. 85: 145-147.
  24. Kumar A, sasmal D and Sharma N. (2015) Mechanism of immunoprotective effects of curcumin in dlm-induced thymic apoptosis and altered immune functions: an in silico and in vitro study. Journal of Immuntoxicology and Immunopharmacology. DOI:
    10.3109/08923973.2015.1091004. 
  25. Divakar D, sasmal D, Kumar A, and Sharma N. (2015) Prophylactic role of piprine and curcumin in allethrin altered hematological and biochemical parameters in Swiss albino mice. Pharmacologia. 6: 396-412.
  26. Kumar A, Sharma N and Sasmal D. (2015). Understanding of statistics in testing of pharmacological hypothesis. Pharmawave. 8:64-72.
  27. Kumar A, dubey R.K, kant K, sasmal D, ghosh M, Sharma N. 2016 Determination of deltamethrin concentration in mice plasma and primary immune organs by simple reverse phase hplc. Acta Chromatographica 28(2016)2, 193–206 DOI: 10.1556/1326.2016.28.2.4.
  28. Sharma, R., Sharma, N., Parmar, R., Chatterjee, V., Kumar, A., Woehrl, N., Buck, V., Barhai, P.K., Nanocrystalline Diamond Films as A Protective Coating For Implantable Bio-devices. Adv. Mat. Lett. 2016, 7 (11), 903-909.
  29. Chakravarty, M., Sharma, R., Kumar A., Sharma, N., Kumar, A. (2016) Synthesis and bio-compatibility study of thermal-CVD grown graphene. Int. J. Nanosci. 15 (5), 1660016.
  30. Kumar A, Sasmal D, Sharma N. (2018) Mechanism of Deltamethrin induced thymic and splenic toxicity in mice and its  protection by Piperine and Curcumin: in vivo study. Drug and Chemical Toxicology. 41 (1), 33-41.
  31. Neelima Sharma, Sayantan Banerjee, Papiya Mitra Mazumder (2018). Evaluation of the mechanism of anticancer activity of deltamethrin in Jurkat-J6 cell line. Pesticide Biochemistry and Physiology, 149 98-103.
  32. Anoop Kumara, Ruchika Sharma, Divya Rana and Neelima Sharma (2019). Protective Effect of Alpha-Tocopherol in Deltamethrin Induced Immunotoxicity. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(2):171-184.
  33. Chugwani V., Sharma N. and Sharma P (2019). A review on MicroRNA- The New Frontier in Cancer Theranostics. PharmBIT; 35:20-27.
  34. Anoop Kumar, Meenakshi GuptaRuchika SharmaNeelima Sharma (2020). Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study. Endocrine, Metabolic & Immune Disorders - Drug Targets 20(1):67-76.
  35. N. Sharma, S. Kispotta, P M. Mazumder (2020). Immunomodulatory and anticancer activity of Bombax ceiba Linn leaf extract. Asian Pac J Trop Biomed, 10(9), 426-432.
  36. Amrita Chatarjee, Neelima Sharma, Papiya Mitra Mazumder. Evaluation of Antioxidant, Immunomodulatory and Anticancer Properties of Methanolic Extract of Neolamarckia cadamba Linn. Fruits. Indian J Pharm Edu Res. 202 (2021), S501-S509.
  37. Neelima Sharma, Ramashish Bhattacharjee, Rishi Sharma. Synthesis of Biocompatible carboxylic acidfunctionalized Graphene Oxide as a stimulator of bacterial growth. Acta Microbiologica Bulgarica.  37 (2021), 195-201.
  38. Prasanti Sharma and Neelima Sharma, Advances in Nano-formulated Polyphenols for protection against Cardiovascular Diseases. Journal of Cardiovascular Pharmacology, 80 (2022), 648-660.
  39. Neha Chakraborty, Rishi Sharma, Rajan Kumar Singh, Sanat Kumar Mukherjee, Neelima Sharma; PEDOT:PSS doped graphene oxide as an alternative to hole transport material and transparent conducting electrode; NANO Vol. 17, No. 11 (2022) 2250115.
  40. Neelima Sharma, Surajit Mondal, Hari Om Yadav, Rishi Sharma, Graphene oxide-Silver Nanocomposite induced apoptosis in human hepatoma (HepG2) cells through oxidative stress and caspase dependent signalling pathway, IJEMS, (2022)
  41. Abhilash Bajpai, Neelima Sharma, Prabhat K. Dwivedi and Rishi Sharma, Rapid fabrication of graphene layers over polymeric substrates using Atmospheric Pressure Plasma Jet, IEEE Transactions on Plasma Science, (2022)
  42. Manisha Kumari, Prasanti Sharma and Neelima Sharma.  Evaluation of anti-anxiety effects of the hydromethanolic extract of Boerhaavia diffusa L. roots in mice exposed to unpredictable chronic mild stress Indian Journal of Natural Products and Resources Vol. 14(2), June 2023, pp. 249-254 DOI: 10.56042/ijnpr.v14i2.4209
  Member of Professional Bodies
 

1. Life member of Society of Toxicology India (STOX, India).

2. Jt. Treasurer of  Pharmaceutical Society, Birla Institute of Technology, Mesra, Ranchi.

  Current Sponsored Projects
 

1. Studies  on  Immunotoxic Profile and Proteomics of Deltamethrin in Murine Thymocytes and Splenocytes: Attenuation by Herbals, Funded by UGC, Major Research Project Scheme, (Principal Investigator) sanctioned amount Rs. 9.30 lakhs, duration: 2011 – 2014.

2. Evaluation of Apoptotic Mechanism of  Deltamethrin as a promising candidate against cancer, funded by BIT, Mesrea, Seed Money Scheme, (Principal Investigator) sanctioned amount Rs. 80,000, duration: 2015 – 2016.

3. Synthesis of Reduced Graphene Oxide- metal nanoparticles for early detection of Hepatocellular Carcinoma through Surface Enhanced Raman Spectroscopy, funded by UGC-DAE CSR, (Principal Investigator), duration: 2022 – 2025.

 

  Text and Reference Books
 

Book Chapters

  1. Sen S, Bal T, Rajora A D, Sharma S, Sharma S R, Sharma N. Conducting polymers as efficient materials for tissue engineering, Conducting Polymers, 2022, (1), 12.
  2. Prasanti Sharma, Neelima Sharma, Anoop Kumar, Nagendra Singh Chauhan, Pooja A Chawla. Natural products in Japanese encephalitis, Natural Products in Vector-Borne Disease Management, 2023, 309-334. 
  3. Prasanti Sharma, Neelima Sharma, Trishna Bal , Gayatri Thappa. Nanofabrication Using Natural Flavonoids For Biomedical Applications, Nanofabrication: Enrapturing Cues and Prodigal Applications- 2023,14.
  Member, Editorial Board
 

1.    Member of the Reviewer Board of Biological Trace Element Research.

        2. Member of the Advisory Board of PHARMBIT.