Organic & Medicinal Chemistry, Development of New Antiviral Molecules

CSIR-CDRI Research Fellowship (2001-2004)

Postdoctoral Fellowship, Center for Complex Carbohydrate Research, Athens, Georgia, USA (2006-2007), College of Pharmacy, University of Georgia, USA (2007-2008)

DST-SERB INTERNATIONAL TRAVEL GRANT AWARD (2015)

1. Trivedi, J.; Parveen, A.; Rozy, F.; Mitra, A.; Bal, C.; Mitra, D.; Sharon, A.; Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity; European Journal of Medicinal Chemistry, 183, 1116999, 2019.
2. Chakravarty, H.; Bal, C.; Yadav, M.; Jena, N.; Bal, N. C.; Sharon, A.; First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers; ACS Omega, 4, 11508, 2019.
3. Ramakrishnamraju Samunuri, R., Jha, A. K., & Bal, C.; Rhodium catalyzed stereospecific reductive
   carbocyclization of 1,6-enynes and synthesis of 4′-methyl-6′-substituted aristeromycins; Nucleotides and Nucleic Acids, 38, 391, 2019, . 
4. Kasula, M.; Toyama, M.; Samunuri, R.; Rozy, F.; Yadav, M.; Bal, C.; Jha, A. K.; Baba, M.; Sharon, A.; Synthesis and anti-HBV activity of α-stereoisomer of aristeromycin based analogs; Bioorg Med Chem Lett; 26, 3945, 2016.
5. Thiyagarajan, A.; Toyama, M.; Baba, M.; Sharon, A.; Bal, C.; Synthesis and anti-HCV activity of 4-methoxy-7H-pyrrolo[2,3-d] pyrimidine carbocyclic nucleosides; Nucleotides and Nucleic Acids, 2016, 35, 305.
6. Kasula, M., Samunuri, R.; Chakravarty, H.; Bal, C.; Baba, M.; Jha, A. K.; Sharon, A.; Regioselective synthesis of pyrazolo[3,4-d] pyrimidine based carbocyclic nucleosides as possible antiviral agent; Nucleosides Nucleotides and Nucleic Acids, 2016, 35, 43.
7. Balaraju, T.; Konreddy, A. K.; Parveen, A.; Toyama, M.; Ito, W.; Karampuri, S.; Baba, M.; Sharon, A.; Bal, C.; Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold; Bioorg Med Chem Lett, 2015, 25, 5224
8. Karampuri, S.; Ojha, D.; Bag, P.; Chakravarty, H.; Bal, C.; Chattopadhyay, D.; Sharon, A. Anti-HSV activity and mode of action study of a-pyrone carboxamides. RSC Adv., 2014, 4, 17354-63.
9. Konreddy, A. K.; Toyama, M.; Ito, W.; Bal, C.; Baba, M.; Sharon, A. Synthesis and Anti-HCV Activity of 4-Hydroxyamino a-Pyranone Carboxamide Analogs. ACS Med. Chem. Lett., 2014, 5, 259-263.
10. Nag, S.; Chouhan, D. K.; Balaji, S. N.; Chakraborty, A.; Lhouvum, K.; Bal, C.; Sharon, A.; Trivedi, V. Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies. Medicinal Chemistry Research, 2013, 22, 4737-4744.
11. 4. Kumar, A.; Chakravarty, H.; Bal, N. C.; Balaraju, T.; Jena, N.; Misra, G.; Bal, C.; Pieroni, E.; Periasamy, M.; Sharon, A. Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization. Molecular Biosystems, 2013, 9, 1949-1957.
12. Kasula, M.; Balaraju, T.; Toyama, M.; Thiyagarajan, A.; Bal, C.; Baba, M.; Sharon, A. A Conformational Mimetic Approach for the Synthesis of Carbocyclic Nucleosides as Anti-HCV Leads. ChemMedChem, 2013, 8, 1673-1680.
13. Karak, M.; Bal, N. C.; Bal, C.; Sharon, A. Targeting peroxisome proliferator-activated receptor gamma for generation of antidiabetic drug. Current diabetes reviews, 2013, 9, 275-85.
14. D. K. Chouhan, A. Sharon, C. Bal Molecular and Structural Insight into Plasmodium Falciparum RIO2 Kinase, J Mol Modeling, 2013, 19, 485-496.
15. A. Thiyagarajan, M. T. A. Salim, T. Balaraju, C. Bal, M. Baba, A. Sharon Structure Based Medicinal Chemistry Approach to Develop 4-Methyl-7-Deazaadenine Carbocyclic Nucleosides as Anti-HCV Agent Bioorg Med Chem Lett, 2012, 22 (24), 7742-7.
16. S. Karampuri, P. Bag, S. Yasmin, D. K. Chouhan, C. Bal, D. Mitra, D. Chattopadhyay, A. Sharon Structure Based Molecular Design, Synthesis and Biological Evaluation of a-Pyrone Analogs as Anti-HSV Agent Bioorg Med Chem Lett, 2012, 22, 6261-6.
17. N. C. Bal, N. Jena, D. Sopariwala, T. Balaraju, S. Shaikh, C. Bal, A. Sharon, S. Gyorke, M. Periasamy, Probing cationic selectivity of Cardiac Calsequestrin and its CPVT mutants, Biochemical Journal, 2011, 435, 391-399.
18. H. Kim, A. Sharon, C. Bal, J. Wang, M. Allu, Z. Huang, M. G. Murray, L. Bassit, R. F. Schinazi, B. Korba and C. K. Chu Synthesis, Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues In Vitro. J Med Chem, 2009, 52, 206-213.

Life Member of Indian Society of Chemists and Biologist (ISCB)

1. Dr. C. Bal (Co-PI); Development of compounds that selectively destroy HIV-1-infected cells. 11 Lacs, Kagoshima University, Japan, (2018-Continue)

COMPLTED PROJECTS:

1. Discovery of HepDirect Nucleotide Prodrug as Anti-Hepatitis B Agent. 18 Lacs (2010-2014) SERB DST:  SR/FT/CS-069/2009.; Feb 02,  2010
2. Winged Helix domain-oligonucleotide recognition as an axis to develop PfRIO-2 specific inhibitor: implication in anti-malarial drug development: DR. C. BAL (PI); 36 Lacs; 2011-2014; DBT: BT/41/NE/TBP/2010.; DEC 22, 2010
3. Synthesis and Evaluation of Carbocyclic Nucleoside Analogs with Exocyclic Double Bond as Anti-HBV HepDirect Prodrug; Dr. C. Bal (PI); 4.4 Lacs; UGC: F. N.39-705/2010(SR): JAN 12, 2011
   
    

1. Jena, N.; Bal, C.; Sharon, A., Plant and marine products: a promising hope in the search of therapeutics against dengue. In Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases, Elsevier: 2019; pp 385-405.

1. Novel pyranone carboxamide derivative and use thereof as Anti-Hepatitis C Virus drug, Masanori Baba, Ashoke Sharon, Chandralata Bal, and Ananda K Konreddy; Publication No: WO2015008779 A1, Application No: PCT/JP2014/068880, Priority Date: July 17, 2013. Publication Date: Jan 22 2015.

2. Anti-hepatitis B virus drugs, Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula, Japanese Patent Application number: JP 2013-254236, Filing date: Dec. 9, 2013.

3. Anti-hepatitis B virus drugs, Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula, Japanese Patent Application number: JP 2013-254238, Filing date: Dec. 9, 2013

GERF Bulletin of Biosciences, The official journal of Green Earth Research Foundation.