Birla Institute of Technology, Mesra
Dr. Rajnish Prakash Singh (Ramalingaswami Fellow)
Assistant Professor, Bioengineering and Biotechnology
M.Sc., M.Tech., Ph.D. 		Contact Address
Permanent Address Suncity, Indira Nagar, Sector-C, Lucknow
Local Address NGHC (National Games Housing Complex) Khelgaon, Hotwar, Ranchi, Jharkhand, 835217
Phone (Office) +91-7439471019
Phone Residence +91-7439471019
Email Id manasrajnish2008@gmail.com
Joined Institute on : 1-Jul-2021
  Work Experience
 
Teaching : 6 Years

Research : 11 Years

Individual: 10 Years
  Professional Background
  • Assistant Professor and Ramalingaswami fellow (July 2021- continue), Birla Institute of Technology (BIT), Mesra, Ranchi, India
  • Postdoctoral Researcher (March 2019- May 2021), Hebrew University of Jerusalem, Israel
  • Postdoctoral Researcher (March 2018-February 2019), Tel-Aviv University, Israel
  • Postdoctoral Researcher (March 2017- February 2018), Indian Institute of Technology Bombay (IIT-B), India
  Research Areas
 
  • Microbial Molecular Biology
  • Molecular Plant Microbe Interaction
  • Environmental Biotechnology
  • Food Chemistry
  • Probiotics 
  • Microbiome
  Award and Honours
 
  • Ramalingaswami Fellow Award-2021
  • Received the various poster and oral award at national and international conferences
  • Travel grant from various funding agencies
  Publications
 

List of Publications. Total citations->1400, h-index- 17, i10 index- 24)

  • Kumari K, Sharma PK, Deb S, Singh RP* (2023) In-depth genome and pan-genome analysis of a metal-resistant bacterium Pseudomonas parafulva OS-1. Frontier in Microbiology (Accepted)

  • Singh RP*, Kumari K (2023) Genome sequence of environmental isolate Staphylococcus aureus OS-6, isolated from a soil sample. ASM-Microbiology Resource Announcements (Accepted)

  • Kumari K, Sharma PK, Ma Y, Singh RP* (2023) First report on the versatile secretome of an environmental isolate Acinetobacter pittii S-30. Current Microbiology (Accepted)

  • Shadan A, Pathak A, Ma Y,  Pathania R,  Singh RP* (2023) Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection. Frontier in Cellular and Infection Microbiology https://doi.org/10.3389/fcimb.2023.1053968

  • Kumari K, Sharma PK, Ma Y, Singh RP* (2023) Secretome of Paenibacillus sp. S-12 provides an insight about its survival and possible pathogenicity. Folia Microbiologica https://doi.org/10.1007/s12223-023-01032-4

  • Singh RP*, Kumari K (2023) Bacterial Type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality. Biotechnology Letters (45(3):309-331

  • Kumari K, Sharma PK, Singh RP* (2023) Unraveling the virulence factors and secreted proteins of an environmental isolate Enterobacter sp. S-16. Current Microbiology 31;80(3):88.

  • Singh RP, Kolton M, Boker M, David NB, Green S , Helman A, Hayouka Z, Tirosh O (2022) Probiotic human alcohol dehydrogenase-4 expressing bacteria protects from diet induced obesity and metabolic impairment: A new concept of disease prevention. Explor Diges Dis (Accepted)

  • Kumari K, Sharma PK, Aggarwal Y, Singh RP* (2022) Secretome analysis of an environmental isolate Enterobacter sp. S-33 identifies proteins related to pathogenicity. Archives of Microbiology 5;204(11):662.
  • Singh RP*, Shadan A, Ma Y(2022) Biotechnological Applications of Probiotics: A Multifarious Weapon to Disease and Metabolic Abnormality. Probiotics and Antimicrobial Proteins https://doi.org/10.1007/s12602-022-09992-8.
  • Singh RP*, Ma Y, Shadan A (2022) Perspective of ACC deamianse-producing bacteria in stress agriculture. Journal of Biotechnology 352:36-46. .
  • Singh RP*, Pandey DM, Jha PN, Ma Y* (2022) ACC deaminase producing rhizobacterium Enterobacter cloacae ZNP-4 enhance abiotic stress tolerance in wheat plant. PLOS One 17:5 e0267127
  • Singh RP, Jha PN (2022) Transposon mutagenesis of ACC deaminase gene alters the proteomic analysis of wheat plant under non-saline and saline stress. J Proteins Proteomics (in-press).
  • Singh RP, Halaka DA, Hayouka Zvi, Tirosh O, High fat diet induced alteration of mice microbiota and the functional ability to utilize fructooligosccharide (FOS) for ethanol production. Frontier in Cellular and Infectious Microbiology (2020) doi: 10.3389/fcimb.2020.00376.
  • Agarwal SD, Singh RP, Jha PN, Sakhuja R, Fabrication of deoxycholic acid tethered α-cyanostilbenes as smart low molecular weight gelators and AIEE probes for bio-imaging. Steroids (2020) 08 18;160:108659.
  • Sandhu M, Jha P, Paul A, Singh RP, Jha PN, Evaluation of biphenyl- and polychlorinated-biphenyl (PCB) degrading Rhodococcus sp. MAPN-1 on growth of Morus alba by pot study. International Journal of Phytoremediation (2020) https://doi.org/10.1080/15226514.2020.1784088.
  • Mir NA, Ramaraju P, Vanaparthi S, Choudhary S, Singh RP, Sharma P, Kant R, Singh R, Sankaranarayanan M, Kumar I, Sequential multicomponent catalytic synthesis of pyrrole-3-carboxaldehydes: Evaluation for antibacterial and antifungal activities along with docking studies. New Journal of Chemistry (2020) DOI: 10.1039/D0NJ03575K.
  • Pallavi B, Singh RP, Jha PN, Chander S, Murugesan S, Sharma P, and Shukla P, Green Synthesis, in-vitro Antimicrobial Evaluation, Docking, and SAR Studies of Potent Quinoline-4-Carboxylic Acids. Letters in Organic Chemistry (2019) 16, 874-883.
  • Nandwana N, Singh RP, Patel, O, Dhiman S, Jha PN, Kumar A, Design and synthesis of Imidazo/Benzimidazo[1,2-c]quinazoline derivatives and evaluation of their antimicrobial activity. ACS Omega (2018) 3 (11), 16338−16346.
  • Singh RP, Jha PN, Priming with ACC-utilizing bacterium attenuated copper toxicity, improved oxidative stress tolerance, and increased phytoextraction capacity in wheat. Environment Science & Pollution Research (2018) 25(33), 33755-33767.
  • Singh RP, Jha PN, Effect of inoculation of zinc-resistant bacterium Enterobacter ludwigii CDP-14 on growth, biochemical parameters and zinc uptake in wheat (Triticum aestivum L.) plant. Ecological Engineering (2018) 116, 163-173.
  • Ashok P, Chander S, Smith TK, Singh RP, Jha PN, Sankaranarayanana M, Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents. Bioorganic Chemistry (2018) 84: 98–105.
  • Nehra P, Khungar B, Singh RP, Sivasubramanian SC, Jha PN, Saini V, Synthesis,characterization and applications of imidazolium ionic liquid-tagged zinc(II) complex. Inorganica Chimica Acta (2018) 478: 260–267.
  • Agarwal DS, Singh RP, Lohitesh K, Jha PN, Chowdhury R, Sakhuja R, Synthesis and evaluation of bile acid amides of α-cyanostilbenes as anticancer agents.  Molecular Diversity (2018) 22(2):305-321.
  • Singh RP, Jha PN, The PGPR Stenotrophomonas maltophila SBP-9 augments resistance against biotic and abiotic stress in wheat plants. Frontier in Microbiology (2017) DOI: doi: 10.3389/fmicb.2017.01945.
  • Singh RP, Runthala A, Khan S, Jha PN, Quantitative proteomic analysis reveals the tolerance of wheat to salt stress in response to Enterobacter cloacae SBP-8. Plos One (2017) 12 (9), e0183513.
  • Singh RP, Jha PN, Bio-inoculation of Plant growth-promoting rhizobacterium Enterobacter cloacae ZNP-3 increased resistance against salt and temperature stress in wheat plant (Triticum aestivum L.) 2017, Journal of Plant Growth Regulation (2017) 36 (3), 783-798, DOI: 10.1007/s00344-017-9683-9.
  • Singh RP, Jha PN, A halotolerant bacterium Bacillus licheniformis HSW-16 augments induced systemic tolerance to salt stress in wheat plant (Triticum aestivum). 2017, Frontiers in Plant Sciences (2017) 7, 1890. doi: 10.3389/fpls.2016.01890.
  • Mishra S, Chauhan P, Gupta S, Raghuvanshi S, Singh RP, Jha PN, CO2 sequestration potential of halo-tolerant bacterium Pseudomonas aeruginosa SSL-4 and its application for recovery of fatty alcohols. Process safety and Environment Protection (2017) 111: 582–591.
  • Singh RP, Jha PN, Analysis of fatty acid composition of PGPR Klebsiella sp. SBP-8 and its role in ameliorating salt stress in wheat. Symbiosis (2017) DOI 10.1007/s13199-017-0477-4.
  • Singh RP, Nalwaya S, Jha PN,  The draft genome sequence of the plant growth promoting rhizospheric bacterium Enterobacter cloacae SBP-8. Genomics Data (2017) 12, 81-83.
  • Singh RP, Jha PN, The multifarious PGPR Serratia marcescens CDP-13 augments induced systemic resistance and enhanced salinity tolerance of wheat (Triticum aestivum L.). 2016, PLOS One (2016) 11(6): e0155026, doi:10.1371/journal, pone.0155026
  • Singh RP, Jha PN, Mitigation of salt stress in wheat plant (Triticum aestivum L.) by ACC deaminase bacterium Enterobacter sp. SBP-6 isolated from Sorghum bicolor. Acta Physiologia Plantarum (2016) 38: 110. DOI 10.1007/s11738-016-2123-9.
  • Reddy POV, Tantak MP, Valdez R, Singh RP, Singh OM, Sadana R, Dalip Kumar, Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents. RSC Advances (2016) 6: 9379.
  • Singh RP, Jha PN, Alleviation of salinity-induced damage on wheat plant by an ACC deaminase-producing halophilic bacterium Serratia sp. SL- 12 isolated from salt lake. Symbiosis (2016) 69 (2): 101–111.
  • Ashok P, Chander S, Chow L M C, Wong ILK, Singh RP, Jha PN, Sankaranarayanan M, Synthesis and in-vitro anti-leishmanial activity of (4-arylpiperazin-1-yl) (1-(thiophen- 2-yl)-9H-pyrido[3,4-b]indol-3-yl)methanone derivatives. Bioorganic chemistry (2016) 70, 100-106.
  • Baig N, Singh RP, Jha PN, Saha AK, Synthesis of glucose-derived glycoconjugates and studies on their antimicrobial activities: Mechanistic insight. Chemistry Select, (2016) DOI: 10.1002/slct.201600786.
  • Singh RP, Shelke GM, kumar A, Jha PN, Biochemistry and genetics of ACC   deaminase: A weapon to 'stress ethylene' produced in plants. Frontier in Microbiology (2015) 6: 937.doi: 10.3389/fmicb.2015.00937.
  • Singh RP, Jha P, Jha PN, The plant growth promoting bacterium Klebsiella sp. SBP-8 confers induced systemic tolerance in wheat (Triticum aestivum) plant under salt stress condition. Journal of Plant Physiology (2015)184: 57-67.
  • Tantak MP, Wang J, Singh RP, Kumar A, Shah K, Dalip Kumar, 2-(3¢-Indolyl)-Narylthiazole- 4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities. Bioorganic & Medicinal Chemistry Letters (2015) 25 (19), 4225-4231.
  • Singh RP, Jha PN, Characterization and optimization of alkaline protease production from Bacillus Licheniformis HSW-16 isolated from Sambhar salt lake. International Journal of Applied Science & Biotechnology (2015) 3: 347-351.
  • Mishra SM, Singh RP, Raghuvanshi S, Jha PN, Deducing the Bio-perspective capabilities of Fe(II) oxidizing bacterium isolated from extreme environment. Biochemistry & Analytical Biochemistry (2015) 4: 166.
  • Baig N, Singh RP, Chander S, Jha PN, Murugesan S, Saha AK, Synthesis, evaluation and molecular docking studies of amino acid derived N-glycoconjugates as antibacterial agents. Bioorganic Chemistry (2015) 63: 110-115.
  • Singh RP, Jha PN, Plant growth promoting potential of ACC deaminase rhizospheric bacteria isolated from Aerva javanica: A plant adapted to saline environments. International Journal of Current Microbiology & Applied Sciences (2015) 4: 142-152.
  • Chander S, Ashok P, Singh RP, Jha PN, Murugesan S, A rapid, green, efficient microwave-assisted synthesis and antimicrobial activity of novel glycinamide of 6,7- dimethoxy-1, 2, 3, 4-tetrahydroisoquinolines. Current Microwave Chemistry (2015) 9: 33.
  • Khedar P, Pericherla K, Singh RP, Jha PN, Kumar A, Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities. Medicinal Chemistry Research (2015) 24: 3117–3126.
  • Pallavi B, Sharma A, Singh RP, Jha PN, Shukla P, Novel grinding synthesis of pyranopyrazole analogues and their evaluation as antimicrobial agents. Heterocycles (2015) 91: 1615-1627.
  • Singh RP, Mishra SM, Raghuvanshi S, Jha PN, GC-MS analysis of change in fatty acid composition of halobacterium Bacillus licheniformis HSW-16 under varying salinity condition. Journal of Microbiology Biotechnology & Food Sciences (2015) 5: 290-292. 
  Current Sponsored Projects
 
  • DBT-Ramalingaswami -2021 (11,360,000/INR) to work on ‘ Molecular characterization of type VI secretion system’
  Intellectual Property Rights (IPR)
 
  • (US Patent, application no.- 63/221,135), Title of invention- Genetically modified bacteria and use there of