Birla Institute of Technology, Mesra
   
Dr. Sandeep Kumar Singh
Associate Professor, Pharmaceutical Sciences and Tech
B. Pharm., IET, MJP Rohilkhand University, Bareilly, UP; M. Pharm. (Pharmaceutics), UIPS, Panjab University Chandigarh; Ph.D (BIT, Mesra); R. Ph.; Postdoc: PKNU (MBRC), Busan, South Korea
Contact Address
Permanent Address C-2/73, First Floor, Near Hostel-6, Outer Campus, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
Local Address B/33/21, C-H-5-1, New Saket Nagar Colony, Sankat Mochan, Varanasi- 221 005, Uttar Pradesh
Phone (Office) +919234653731
Phone Residence +919234653731
Email Id sandeep.singh@bitmesra.ac.in
Joined Institute on : 17-Oct-2006
  Work Experience
 
Teaching : 16 Years

Research : 16 Years

  Professional Background
  1. Postdoc, Marine Bioprocess Research Center, Department of Marine Bio-convergence Science, Pukyong National University, Busan, South Korea 
  2. Ph.D., 2010, Birla Institute of Technology, Mesra, Ranchi.
  3. M.Pharm. (Pharmaceutics), 2002, with 68% (1st Class) from University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh.
  4. B.Pharm., 2000, with 78% (1st Class with Honours) from Institute of Engineering and Technology, M.J.P. Rohilkhand University, Bareilly.
  Research Areas
 
  1. Lipid Based Drug Delivery System
  2. Silk Nanoparticles
  3. Nanoparticle Based Drug Delivery System
  4. Self Nanoemulsifying Drug Delivery System
  5. In silico Pharmacokinetics Simulations
  6. Marine Pharmaceutics
  Award and Honours
 
  1. Recipient of PKNU-Industry Research Award (45,000,000.00 KRW) for Postdoctoral Research
  2. K.D. Chaudhary Oration Award for Oral Presentation on Development of Self Nanoemulsifying Drug Delivery System of Carvedilol Loaded SNEDDS Formulation RIMS, Pharmacon.
  3. Recipient of Birla Institute of Technology Senior Research Fellowship for pursuing Doctoral Research
   Publications
 

RESEARCHER ID LINK     ORCID LINK

2020

50. Das, S.S., Verma, P.R.P., Singh, S.K. (2020). Screening and preparation of quercetin doped nanoemulsion: characterizations, antioxidant and anti-bacterial activities. LWT Food Science and Technology. 124:109141. doi: 10.1016/j.lwt.2020.109141.

49. Mallick A., Gupta, A., Hussain, A., Aparajay, P., Singh, S., Singh, S.K., Dev, A. (2020).  Intranasal delivery of gabapentin loaded optimized nanoemulsion for augmented permeation. Journal of Drug Delivery Science and Technology. 56:101606. doi: 10.1016/j.jddst.2020.101606.

48. Hussain, A., Altamimi, M.A., Alshehri, S., Imam, S.S., Shakeel, F., Singh, S.K. (2020). Novel Approach for Transdermal Delivery of Rifampicin to Induce Synergistic Antimycobacterial Effects Against Cutaneous and Systemic Tuberculosis Using a Cationic Nanoemulsion Gel. International Journal of Nanomedicine. 15:1073-94. doi: 10.2147/ijn.s236277.

47. Das, S.S., Hussain, A., Imam, S.S., Altamimi, M.A., Alshehri, S., Verma, P.R.P., Singh, S.K., (2020). Recent advances in liposomal drug delivery system of Quercetin for cancer targeting: A mechanistic approach. Current Drug Delivery. (Accepted). 

46. Singh, N., Hussain, A., Singh, S.K. (2020). Morphological transitions of Bacillus subtilis in the presence of food-grade lipidic nanoemulsions. Journal of Food Science. In press. doi: 10.1111/1750-3841.15088.

2019

45. Hussain, A., Shakeel, F., Singh, S. K., Alsarra, I. A., Faruk, A., Alanazi, F. K., & Peter Christoper, G. V. (2019). Solidified SNEDDS for the oral delivery of rifampicin: Evaluation, proof of concept, in vivo kinetics, and in silico GastroPlusTM simulation. International Journal of Pharmaceutics, 566, 203-217. doi: https://doi.org/10.1016/j.ijpharm.2019.05.061.

44. Singh, A., Singh, S.K. (2019). The impact of various drug ferrying additives on phase transitions behavior of Calcite, Vaterite and Aragonite. Phase Transitions. 92(11):990-1008. doi: 10.1080/01411594.2019.1670829.

2018

43. Ali, H., & Singh, S. K. (2018). Preparation and characterization of solid lipid nanoparticles of furosemide using quality by design. Particulate Science and Technology, 36(6), 695-709. doi: 10.1080/02726351.2017.1295293.

42. Venkatesan, J., Singh, S. K., Anil, S., Kim, S.-K., & Shim, M. S. (2018). Preparation, characterization and biological applications of biosynthesized silver nanoparticles with chitosan-fucoidan coating. Molecules, 23(6), 1429. doi: 10.3390/molecules23061429.

2017

41. Kumar, S., & Singh, S. K. (2017). Fabrication and characterization of fibroin solution and nanoparticle from silk fibres of Bombyx mori. Particulate Science and Technology, 35(3), 304-313. doi: 10.1080/02726351.2016.1154908.

40. Kumar, S., & Singh, S. K. (2017). In silico-in vitro-in vivo studies of experimentally designed carvedilol loaded silk fibroin-casein nanoparticles using physiological based pharmacokinetic model. International Journal of Biological Macromolecules, 96, 403-420. doi: 10.1016/j.ijbiomac.2016.12.052.

39. Geroge, J. K., Verma, P. R. P., Venkatesan, J., Lee, J.-Y., Yoon, D.-H., Kim, S.-K., & Singh, S. K. (2017). Studies on Core-Shell Nano capsules of Felodipine: In Vitro-In Vivo Evaluations. AAPS PharmSciTech, 18(8), 2871-2888. doi: 10.1208/s12249-017-0770-9.

38. Praveen, R., Prasad Verma, P. R., Venkatesan, J., Yoon, D.-H., Kim, S.-K., & Singh, S. K. (2017). In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus™. International Journal of Biological Macromolecules, 102, 642-650. doi: 10.1016/j.ijbiomac.2017.04.067.

37. Hussain, A., Kumar Singh, S., Ranjan Prasad Verma, P., Singh, N., & Jalees Ahmad, F. (2017). Experimental design-based optimization of lipid nanocarrier as delivery system against Mycobacterium species: in vitro and in vivo evaluation. Pharmaceutical Development and Technology, 22(7), 910-927. doi: 10.1080/10837450.2016.1212879.

36. Radhakrishnan, P., Singh, S. K., & Verma, P. R. (2017). Pharmaceutical formulations to increase gastric residence time: Concepts and strategies. Drug Delivery Letters, 7(3), 190-200. doi: 10.2174/2210303107666170428102247.

35. Prasad, R., Radhakrishnan, P., Singh, S. K., & Verma, P. R. (2017). Furosemide–Soluplus® Solid Dispersion: Development and Characterization. Recent Patents on Drug Delivery & Formulation, 11(3), 211-220. doi: 10.2174/1872211311666171129120020.

34. Ali, H., Verma, P. R. P., Dubey, S. K., Venkatesan, J., Seo, Y., Kim, S.-K., & Singh, S. K. (2017). In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using GastroPlus™. RSC Advances, 7(53), 33314-33326. doi: 10.1039/C7RA04038E.

33. Bhattacharjee, A., Verma, S., Verma, P. R. P., Singh, S. K., & Chakraborty, A. (2017). Fabrication of liquid and solid self-double emulsifying drug delivery system of atenolol by response surface methodology. Journal of Drug Delivery Science and Technology, 41, 45-57. doi: 10.1016/j.jddst.2017.06.014.

2016

32. Hussain, A., & Singh, S. K. (2016). Evidences for anti-mycobacterium activities of lipids and surfactants. World Journal of Microbiology and Biotechnology, 32(1), 7. doi: 10.1007/s11274-015-1965-4.

31. Praveen, R., Singh, S. K., & Verma, P. R. P. (2016). Pharmacokinetic evaluation of cefdinir-loaded floating alginate beads in rabbits using LC–MS/MS. Journal of Pharmaceutical Investigation, 46(3), 283-291. doi: 10.1007/s40005-016-0234-3.

30. Dinesh Kumar, V., Verma, P. R. P., & Singh, S. K. (2016). Morphological and in vitro antibacterial efficacy of quercetin loaded nanoparticles against food-borne microorganisms. LWT - Food Science and Technology, 66, 638-650. doi: 10.1016/j.lwt.2015.11.004.

29. George, J. K., Singh, S. K., & Verma, P. (2016). In vivo in silico pharmacokinetic simulation studies of carvedilol-loaded nano capsules using GastroPlus™. Therapeutic Delivery, 7(5), 305-318. doi: 10.4155/tde-2015-0004.

28. Hussain, A., Haque, M. W., Singh, S. K., & Ahmed, F. J. (2016). Optimized permeation enhancer for topical delivery of 5-fluorouracil-loaded elastic liposome using Design Expert: part II. Drug Delivery, 23(4), 1242-1253. doi: 10.3109/10717544.2015.1124473.

27. Verma, S., & Singh, S. K. (2016). LC-ESI-MS/MS estimation of loratadine-loaded self-nanoemulsifying drug delivery systems in rat plasma: Pharmacokinetic evaluation and computer simulations by GastroPlus™. Journal of Pharmaceutical and Biomedical Analysis, 124, 10-21. doi: 10.1016/j.jpba.2016.02.008.

26. Verma, S., Singh, S. K., & Verma, P. R. P. (2016). Fabrication of lipidic nanocarriers of loratadine for facilitated intestinal permeation using multivariate design approach. Drug Development and Industrial Pharmacy, 42(2), 288-306. doi: 10.3109/03639045.2015.1052078.

25. Verma, S., Singh, S. K., & Verma, P. R. P. (2016). Solidified SNEDDS of loratadine: formulation using hydrophilic and hydrophobic grades of Aerosil®, pharmacokinetic evaluations and in vivo–in silico predictions using GastroPlus™. RSC Advances, 6(4), 3099-3116. doi: 10.1039/C5RA21796B.

24. Praveen, R., Singh, S. K., & Verma, P. R. P. (2016). Pharmacokinetic evaluation of cefdinir-loaded floating alginate beads in rabbits using LC–MS/MS. Journal of Pharmaceutical Investigation, 46(3), 283-291. doi: 10.1007/s40005-016-0234-3.

23. Hussain, A., Singh, S. K., Singh, N., & Prasad Verma, P. R. (2016). In vitro–in vivo–in silico simulation studies of anti-tubercular drugs doped with a self-nanoemulsifying drug delivery system. RSC Advances, 6(95), 93147-93161. doi: 10.1039/C6RA14122F.

22. Ali, H., & Singh, S. K. (2016). Biological voyage of solid lipid nanoparticles: a proficient carrier in nanomedicine. Therapeutic Delivery, 7(10), 691-709. doi: 10.4155/tde-2016-0038.

21. Hussain, A., Samad, A., Singh, S. K., Ahsan, M. N., Haque, M. W., Faruk, A., & Ahmed, F. J. (2016). Nano emulsion gel-based topical delivery of an antifungal drug: in vitro activity and in vivo evaluation. Drug Delivery, 23(2), 642-657. doi: 10.3109/10717544.2014.933284.

2015

20. Singh, N., Verma, S. M., Singh, S. K., & Verma, P. R. P. (2015). Antibacterial action of lipidic nano emulsions using atomic force microscopy and scanning electron microscopy on Escherichia coli. Journal of Experimental Nanoscience, 10(5), 381-391. doi: 10.1080/17458080.2013.838702.

19. Singh, N., Verma, S. M., Singh, S. K., & Verma, P. R. P. (2015). Evidence for bactericidal activities of lipidic nano emulsions against Pseudomonas aeruginosa. Antonie Van Leeuwenhoek, 107(6), 1555-1568. doi: 10.1007/s10482-015-0449-8.

18. Ali, H., Singh, S. K., & Verma, P. R. P. (2015). Preformulation and physicochemical interaction study of furosemide with different solid lipids. Journal of Pharmaceutical Investigation, 45(4), 385-398. doi: 10.1007/s40005-015-0191-2.

17. George, J. K., Singh, S. K., & Verma, P. R. P. (2015). Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design. Journal of Pharmaceutical Investigation, 45(6), 561-578. doi: 10.1007/s40005-015-0204-1.

16. V.D. Kumar., Verma, P. R. P., Singh, S. K., & Viswanathan, S. (2015). LC-ESI-MS/MS analysis of quercetin in rat plasma after oral administration of biodegradable nanoparticles. Biomedical chromatography: BMC, 29(11), 1731-1736. doi: 10.1002/bmc.3486.

15. Dinesh Kumar, V., Verma, P. R. P., & Singh, S. K. (2015). Development and evaluation of biodegradable polymeric nanoparticles for the effective delivery of quercetin using a quality by design approach. LWT - Food Science and Technology, 61(2), 330-338. doi: 10.1016/j.lwt.2014.12.020

14. Hussain, A., Samad, A., Singh, S. K., Ahsan, M. N., Faruk, A., & Ahmed, F. J. (2015). Enhanced stability and permeation potential of nano emulsion containing sefsol-218 oil for topical delivery of amphotericin B. Drug Development and Industrial Pharmacy, 41(5), 780-790. doi: 10.3109/03639045.2014.902957

13. Singh, N., Verma, S. M., Singh, S. K., Verma, P. R. P., & Ahsan, M. N. (2015). Antibacterial activity of cationised and non-cationised placebo lipidic nanoemulsion using transmission electron microscopy. Journal of Experimental Nanoscience, 10(4), 299-309. doi: 10.1080/17458080.2013.830199

2014

12. Ahsan, M. N., Verma, P. R. P., Singh, S. K., Samridhi, & Yashpal, M. (2014). Formulation of rosuvastatin-loaded self-nanoemulsifying drug delivery system using box-Behnken design. Particulate Science and Technology, 32(1), 46-60. doi: 10.1080/02726351.2013.800929

11. Dinesh Kumar, V., Ranjan Prasad Verma, P., & Kumar Singh, S. (2014). New insights into the diagnosis and chemotherapy for visceral leishmaniasis. Current Drug Delivery, 11(2), 200-213. doi: 10.2174/15672018113106660057

10. Praveen, R., Singh, S. K., Verma, P. R. P., & George, J. K. (2014). Sustained delivery of cefdinir to upper gastrointestinal tract using calcium alginate beads: a formulation by design. Journal of Pharmaceutical Investigation, 44(6), 455-463. doi: 10.1007/s40005-014-0139-y

9. Singh, N., Verma, S. M., Singh, S. K., & Verma, P. R. P. (2014). Consequences of lipidic nano emulsions on membrane integrity and ultrastructural morphology of Staphylococcus aureus. Materials Research Express, 1(2), 025401. doi: 10.1088/2053-1591/1/2/025401

8. Verma, S., Singh, S. K., Verma, P. R., & Ahsan, M. N. (2014). Formulation by design of felodipine loaded liquid and solid self-nanoemulsifying drug delivery systems using Box-Behnken design. Drug Development and Industrial Pharmacy, 40(10), 1358-1370. doi: 10.3109/03639045.2013.819884

2013

7. Bhagat, C., Singh, S. K., Verma, P. R. P., Singh, N., Verma, S., & Ahsan, M. N. (2013). Crystalline and amorphous carvedilol-loaded nano emulsions: formulation optimisation using response surface methodology. Journal of Experimental Nanoscience8(7-8),971-992. doi: 10.1080/17458080.2011.630037

2012

6. Saini, R., Singh, S. K., & Verma, P. R. P. (2012). Evaluation of carvedilol-loaded micro sponges with nanometric pores using response surface methodology. Journal of Experimental Nanoscience, 9(8), 831-850. doi: 10.1080/17458080.2012.725258

2011

5. Singh, S. K., Verma, P. R. P., & Razdan, B. (2011). Atomic force microscopy, transmission electron microscopy, and photon correlation spectroscopy: three techniques for rapid characterization of optimized self-nanoemulsifying drug delivery system of glibenclamide, carvedilol, and lovastatin. Journal of Dispersion Science and Technology, 32(4), 538-545. doi: 10.1080/01932691003757157

4. Singh, S. K., Verma, P. R. P., & Razdan, B. (2011). Structural Transitions of Self-Nanoemulsifying Drug Delivery System of Glibenclamide, Carvedilol, and Lovastatin upon Progressive Aqueous Dilution. Journal of Dispersion Science and Technology, 32(6), 771-777. doi: 10.1080/01932691.2010.488126

2010

3. Singh, S. K., Verma, P. R., & Razdan, B. (2010). Glibenclamide-loaded self-nanoemulsifying drug delivery system: development and characterization. Drug Development and Industrial Pharmacy, 36(8), 933-945. doi: 10.3109/03639040903585143

2. Singh, S. K., Verma, P. R., & Razdan, B. (2010). Development and characterization of a lovastatin-loaded self-micro emulsifying drug delivery system. Pharmaceutical Development and Technology, 15(5), 469-483. doi: 10.3109/10837450903286537

2009

1. Singh, S. K., Verma, P. R. P., & Razdan, B. (2009). Development and characterization of a carvedilol-loaded self-micro emulsifying delivery system. Clinical Research and Regulatory Affairs, 26(3), 50-64. doi: 10.1080/10601330903143942.

  Member of Professional Bodies
 
  1. Member, The Korean Society for Biotechnology and Bioengineering
  2. Registered Pharmacist with Pharmacy Council of Union Territory, Chandigarh
  3. Member, Indian Pharmaceutical Association
  Current Sponsored Projects
 
  1. Design, Development and Optimization of Self Nanoemulsifying and Solidified Selfnanoemulsifying Drug Delivery Systems of Anti-tubercular Drugs, Department of Biotechnology, Government of India, 14.50 Lakhs (Indian Rupees): Completed

  2. Antitubercular Drug Loaded of Novel Cubosomes/Hexosomes Based Drug Delivery System Using Response Surface Methodology, University Grant Commission, Government of India: 6.0 Lakhs (Indian Rupees): Completed

  Text and Reference Books
 
  1. Das, S. S., Verma, P. R. P. and Sandeep Kumar Singh (2019) Quercetin Loaded Nanomedicine as Nutritional Applications. Nanomedicine for Bioactives - Healthcare applications, Springer Nature Singapore Pte Ltd. doi: 10.1007/978-981-15-1664-1_9
  2. Das, S. S., Verma, P. R. P. and Sandeep Kumar Singh (2020) Phytoconstituents Centered Byproducts and Nanomedicines as Leishmanicidal Scavengers. Inflammatory biomarkers as Targeted Herbal drug discovery tool: A Pharmacological approach to nanomedicines, AAP, CRC Press, Taylor & Francis Group, USA. (Accepted)
  3. Das S.S., Verma P.R.P., Sandeep Kumar Singh (2020). Analytical Quality by Design for Size-Exclusion Chromatography. In: Handbook of Analytical Quality by Design. Eds: Sarwar Beg, M Saquib Hasnain, Mahfoozur Rahman, Waleed H. Almalki. Elsevier, Accepted
  4. Das, S. S., Verma, P. R. P.; Kar, S. and Sandeep Kumar Singh (2019) Quercetin Loaded Nanomedicine as Oncotherapy. Nanomedicine for Bioactives - Healthcare applications, Springer Nature Singapore Pte Ltd. doi: 10.1007/978-981-15-1664-1_5
  5. Das, S. S., Singh, A., Kar, S., Ghosh, R., Pal, M., Fatima, M., Singh, N. & Sandeep Kumar Singh (2019). Application of QbD Framework for Development of Self-Emulsifying Drug Delivery Systems. In S. Beg & M.S. Hasnain (Eds.), Pharmaceutical Quality by Design: Principles and Applications (pp. 297-350). San Diego, CA: Elsevier Academic Press. doi: 10.1016/B978-0-12-815799-2.00015-0
  6. Jayachandran Venkatesan, Sukumaran Anil, Sandeep Kumar Singh and Se-Kwon Kim (2018). Recent Advances of Alginate Biomaterials in Tissue Engineering (Chapter 9). In: Marine Polysaccharides: Advances and Multifaceted Applications. Eds: Shakeel Ahmed and Aisverya Soundararajan. pp. 207-233
  7. Jayachandran Venkatesan, Sukumaran Anil, Sandeep Kumar Singh, Se-Kwon Kim (2017). Preparation and Applications of Alginate Nanoparticles (Chapter 13). In: Seaweed Polysaccharides (First Edition). Eds: Jayachandran Venkatesan, Sukumaran Anil and Se-Kwon Kim. pp. 249-266. USA, Elsevier   
  8. Sandeep Kumar Singh (2015). Regulatory requirement for product approvals, (Chapter 3),In: Drug Regulatory Affairs. CBS Publishers and Distributors. First edition, 2015, pp 61-86.

 

  Fellow
 

Ph. D Students: (Awarded: 06; ongoing: 03)

Awarded (06)

  1. Dr. Samridhi Verma (PhD/PH/10002/2011); DST-INSPIRE FELLOW, Title: Studies on Self-Emulsifying Systems as Nanocarriers of Loratadine Using Formulation by Design Approach.
  2. Dr. Praveen R (PhD/PH/1061/2010); UGC-BSR FELLOW, Title: Design, Development and Evaluation of Gastroretentive Delivery System of some Poorly Absorbable Drugs.
  3. Dr. Jerome K Geroge (PhD/PH/1004/2011); UGC-BSR FELLOW, Title: Design, Development and Evaluation of Nanocapsules Based Drug Delivery System of Some Drugs.
  4. Dr. Afzal Hussain (PhD/PH/10005/2012); DBT-SRF FELLOW, Design, Development and Evaluation of Lipid Based Nanoparticle of Some Anti-Tubercular Drugs.
  5. Dr. Sandeep Kumar (PhD/PH/10017/2012); UGC-BSR FELLOW, Title: Design, Development and Optimization of Carvedilol Loaded Silk Nanoparticle.
  6. Dr. Hasan Ali (PhD/PH/10013/2012); UGC-BSR FELLOW, Title: Design, Development and Evaluation of Solid Lipid Nanoparticles of Furosemide

Ongoing (03)

  1. Sabyasachi Das (PhD/PH/10006/2017); SELF-SPONSORED, Formulation Development and Evaluation of Quercetin Loaded Nanoparticles Using Quality-by Design Approach
  2. Avi Singh (PhD/PH/10004/2018), DST INSPIRE FELLOW,  Design, Development and Evaluation of Nanoparticles of Some Poorly Water Soluble Drugs Using Formulation by Design Approach
  3. Mahendra Pratap Swain (PhD/PH/1010/2019). AICTE-NDF FELLOW, Development and Evaluation of Transdermal Delivery Systems of Some Drugs
  Member, Editorial Board
 

 1. Mathews Journal of Pharmaceutical Sciences